نتایج جستجو برای: malarial parasites
تعداد نتایج: 42725 فیلتر نتایج به سال:
Chemotherapy of apicomplexan parasites is limited by emerging drug resistance or lack of novel targets. PfHT1, the Plasmodium falciparum hexose transporter 1, is a promising new drug target because asexual-stage malarial parasites depend wholly on glucose for energy. We have performed a comparative functional characterization of PfHT1 and hexose transporters of the simian malarial parasite P. k...
Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of drug-resistant malarial parasites, novel drug targets and lead compounds are urgently required for the development of new therapeutic strategies. Here, we address this important problem by targeting the malarial neutral aminopeptidases that are inv...
OBJECTIVES To develop and evaluate a rapid method for the diagnosis of malaria infection by microscopy of stained blood films. SUBJECTS AND METHODS Blood specimens were collected from randomly selected confirmed malaria cases (n = 75) and suspected malaria cases (n = 175). The microscopy was done on each set of blood films stained by modified and the standard Giemsa staining methods. RESULT...
Malarial parasites are expected to induce haematological alterations but reports on changes in haematological parameters during malaria among adults in Southwest Nigeria are not well documented. To investigate the effect of acute malaria on some haematological indices, a sample of 5 ml of venous blood was drawn from each of 671 adults with acute malarial infection and 523 apparently healthy sub...
Malaria still poses a threat to the health of residents and travellers in tropical countries, which causes high morbidity and mortality. The present study was undertaken for cultivation of the Plasmodium vivax in McCoy’s 5A medium and observed for their growth. Cultivation of Plasmodium vivax was done according to modified method of Jensen and Trager (1980) in immature red blood cells (reticulo...
upon by me the next morning-. Amputation by the modified circular method was performed a few inches below the shoulder joint, and a drainage tube inserted. The following are brief notes of this case after operation:? 28-7-26. Temperature 102.5 ?F in the morning, and 103?F in the evening. One pint of saline given intravenously. Blood films examined for malarial parasites with negative result. 10...
The continuous culture of Plasmodium falciparum is often seen as a means to an end, that end being to probe the biology of the parasite in question, and ultimately for many in the malaria drug discovery arena, to identify means of killing the parasite in order to treat malaria. In vitro continuous culture of Plasmodium falciparum is a fundamental requirement when undertaking malaria research wh...
Ameliorative antimalarial effects of the combination of rutin and swertiamarin on malarial parasites
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