antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

background: malaria is well known for its fatalities worldwide, plasmodium vivax and the plasmodium falciparum are the two important species of malaria reported from pakistan and creating lots of morbidities across the country. method: study was conducted to determine the surveillance of malaria in south punjab by microscopy and polymerase chain reaction (pcr). result : 40 samples out of 100 pa...

malaria is a major problem in tropical and sub-tropical countries, with high morbidity and mortality. splenectomy makes patients more susceptible to serious bacterial and parasitic infections. we report for the first time in iran a fatal case of plasmodium vivax malaria, confirmed by microscopic and molecu­lar (semi-nested multiplex pcr) tests in a patient who had undergone splenectomy due to h...

southeast of iran is an endemic area for malaria and crimean-congo hemorrhagic fever ( cchf). in 1999, we faced with an outbreak of cchf in sistan and baluchistan province, in the border of paki­stan and afghanistan. the most cases of malaria in iran are also reported from this area. this arti­cle presents a 17-year- old woman who admitted to our hospital because of acute fever, head­ache, epis...

ahaptoglobinemia is a common phenomenon in tropical countries,where it is probably due to malaria-induced haemolysis. previous studies have suggested that ahaptoglobinemia is more useful than the other parasite detection indexes to estimate the endemicity of malaria. the present study shows the relationship between malaria and haptoglobin, as a genetic marker in balouch population of sistan & b...

introduction: amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated in detail. this article presents and reviews a case of amodiaquine-associated asthenia. a literature search for the characteristics of this adv...

infection resulting from plasmodium vivax is the commonest type found in india as well as other tropical regions. the clini­cal picture is variable depending on the nature, immunity of the child, and lives in an endemic area or not. here, we report a child, who presented with cerebellar dysfunction with intact sensorium and plasmodium vivax was positive on peripheral smear.

in the course of serological and parasitological studies of malaria, 1,018 persons were examined. they were from four different areas (a, b, c and d) in the region of bandar abbas and 1-1ina), southern iran, where malaria is still endemic. for the serological examinations, the ifat was used with p. falciparum and p.vivax antigens. several fa-positive reactions were observed in young children, m...

objectives microscopy of giemsa-stained thick and thin peripheral blood smear (pbs) remains as the standard laboratory method for the diagnosis of symptomatic malaria. this study was done to compare pbs with polymerase chain reaction (pcr) method for detecting asymptomatic malaria parasitemia. patients and method blood samples were collected from 900 asymptomatic school children between 7-11 ye...