abstract introduction : celiac disease (cd) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.  this study reports evaluated prevalence of cd in patients with beta-thalassemia major. materials and methods: in this case-control study in a period of 3 years  which was performed on 620 children in two groups of  beta-thalassemia major  patients (n=20...

background: major thalassemia is an autosomal recessive disease with complications, mortality and serious pathology. today, the life expectancy of patients with major thalassemia has increased along with therapeutic advances. therefore, they need lifelong care, and caring for them would incur many costs. being aware of the patients’ costs can be effective for controlling and managing the costs ...

background: iron-mediated cardiomyopathy is the main complication of thalassemia major (tm) patients. therefore, there is an important clinical need in the early diagnosis and risk stratification of patients. the aim of this study was to evaluate the efficacy of tissue doppler imaging (tdi) to study cardiac iron overload in patients with tm using t2* magnetic resonance (mr) as the gold-standard...

background: molecular diversity of leishmania major and its morphological changes have become a controversial issue among researchers. some aspects of polymorphic shapes of amastigotes in clinical manifestations along with molecular variation were evaluated among suspected patients of some exceptional zoonotic cutaneous leishmaniasis locations in northern khuzestan, southwestern iran. methods: ...

it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...

purpose rupture of pectoralis major (pm) occurs most commonly as a result of an indirect mechanism associated with extensive tension on a maximally contracted muscle. patients with pm tendon ruptures, classically present a history of sudden severe pain in arm and shoulder at the time of injury. treatment options vary from conservative to operative. in cases with total or near-total injuries, su...

objective(s) leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. the a2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (vl). the previous results confirmed that in leishmania infantum, several a2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. as there are ...

vinca minor, vinca major, vinca variegata and vinca rosea are different species of vinca genus, of apocynaceae family. in addition to ornamental applications, they are placed in the group of medicinal plants , because of the various alkaloids they possess. the purpose of this research was the investigation of the antileishmanial effects of the methanolic and crude extracts of leaves and stems o...

background: hepatitis-c infection is a major problem in chronically transfused patients. we compared interferon-α (inf-α) monotherapy with combination of inf-α and amantadine in the treatment of β-thalassemia major patients who were chronically infected with hcv.materials and methods: forty six thalassemia major patients who were chronically infected with hcv were randomly divided into two grou...

background: major depression is a common disorder with great social and individual burdens. transcranial sonography (tcs) is a useful and noninvasive measure for assessment of normal and impaired brain parenchyma. the brainstem raphe nuclei are in close association with dorsocaudal limbic system and plays an important role in depression. in this study we compared the echogenicity of the raphe n...