The expansion of the genetic alphabet with an additional, artificial base pair is of high relevance for numerous applications in synthetic biology. The enzymatic construction of metal base pairs is an alluring strategy that would ensure orthogonality to canonical nucleic acids. So far, very little is known on the enzymatic fabrication of metal base pairs. Here, we report on the synthesis and th...

Epidemiological evidence suggests that high consumption of Brassica genus vegetables, such as broccoli, cabbage, and Brussels sprouts, is very effective in reducing the risks of several types of cancers. 3,3'-Diindolylmethane (DIM), one of the most abundant and biologically active dietary compounds derived from Brassica genus vegetables, displays remarkable antitumor activity against several ex...

This paper investigates several dynamically de ned dimensions for rational maps f on the Riemann sphere, and gives a systematic development modeled on the theory for Kleinian groups. The radial Julia set is de ned and we show H: dim(Jrad(f)) = (f), the minimal dimension of an f -invariant density. The map f is geometrically nite if every critical point in the Julia set is preperiodic. In this c...

Abstract We present a new regularization method, for d dim (Euclidean) quantum field theories in the continuum formalism, based on the domain wall configuration in (1+d) dim space-time. It is inspired by the recent progress in the chiral fermions on the lattice. The wall ”height” is given by 1/M , where M is a regularization mass parameter and appears as a 1+d dim Dirac fermion mass. The presen...

We show that for each 1 ≤ α < d and K < ∞ there is a subset X of R such that dim(f(X)) ≥ α = dim(X) for every K -quasiconformal map, but such that dim(g(X)) can be made as small as we wish for some quasiconformal g , i.e., the conformal dimension of X is zero. These sets are then used to construct new examples of minimal sets for conformal dimension and sets where the conformal dimension is not...

elevated levels of C-reactive protein, and it persisted after the acute event. Moreover, TCR dim cells were also more represented within CD8 T cell, NK, and CD4 CD28 T cell subsets in ACS compared to CSA and controls. Finally, CD4 and CD8 TCR dim T cells isolated from ACS displayed an enhanced transendothelial migratory capacity. Conclusions—TCR dim T cells, an effector T-cell subset with trans...

OBJECTIVE Our purpose is to conduct an epidemiological study of chronic fatigue syndrome (CFS) and its syndrome types and symptoms of traditional Chinese medicine (TCM) among adults (20-50 years old) in Hong Kong, and to discuss the TCM pathogenesis. METHODS DESIGN Cross-sectional questionnaire survey. MEASURES Demographic data, CDC (1994) CFS diagnostic criteria, Trudie Chalder fatigue ...

OBJECTIVE Studies suggest the implication of CD16(+) subpopulations (CD14(+)CD16(+), CD14(dim)CD16(+)) in inflammatory diseases. We aimed to determine the frequency of these subpopulations during weight loss in obesity and diabetes, conditions associated with changes in systemic inflammation, and we tested the link with subclinical atherosclerosis. METHODS AND RESULTS CD14(dim)CD16(+) and CD1...

The transcriptional program controlling the circadian rhythm requires coordinated regulation of chromatin. Characterization of the chromodomain helicase DNA-binding enzyme CHD1 revealed DNA methylation in the promoter of the central clock gene frequency (frq) in Neurospora crassa. In this report, we show that the DNA methylation at frq is not only dependent on the DNA methyltransferase DIM-2 bu...

Indole-3-carbinol (I3C) and its dimer diindolylmethane (DIM) are bioactive metabolites of a glucosinolate, glucobrassicin, found in cruciferous vegetables. Both I3C and DIM have been reported to possess pro-apoptotic, anti-proliferative and anti-carcinogenic properties via modulation of immune pathways. However, results from these studies remain inconclusive since they lack thorough evaluation ...