Introduction: Meningiomas are a group of neoplasms showing spectrum histopathological variants, mostly corresponding to World Health Organization (WHO) grade I. However, certain histologic variants correspond histologically WHO grades II and III. In this study, the adult as well paediatric meningiomas received in our department over last 12 years is being revisited with aim analyse various asse...

To the Editor: A 10-year-old boy was evaluated for a large, painless mass on the left parietal aspect of his skull. A CT scan revealed a complex mass that appeared to arise from the bone (Figure 1a), which was concerning for a primary sarcoma given extensive periosteal reaction. A subsequent MRI showed a large 10.8 × 6.2 × 9.3 cm mass centered in the left parietal bone with both extra-axial int...

Meningiomas, one of the largest subgroup of intracranial tumours are generally benign, but can progress to malignancy. They are classified into the three World Health Organization grades: benign, atypical and anaplastic meningiomas. Various histopathological features have been associated with aggressiveness or recurrence. Several genes have been suggested as prognostic factors, but molecular si...

OBJECTIVE: This study was designed to test two kinds of latent blood reagents, luminol and Bluestar® Magnum, and to determine their ability to detect latent blood and to preserve DNA for genetic profile determinations. DESIGN: Three dilutions of blood were applied to six substrates: vinyl tile, ceramic tile, treated and untreated wood, carpet and cinderblock. Each blood dilution, 1:1, 1:10 and ...

Three cases of multiple spinal canal meningiomas are presented, bringing the total number of documented cases in the American literature to nine. While the exact incidence of multiple spinal meningiomas is difficult to determine, their possible occurrence warrants careful myelographic examination of the whole spinal canal, particularly if multiple clinical levels are present. When a complete bl...

BACKGROUND Meningiomas are common intracranial tumors. Recently, histogenetic and phenotypic similarities between meningiomas and mesotheliomas have been proposed. We were interested in whether these similarities are reflected on the immunohistochemical level, which would add new potentially diagnostic markers for meningiomas. METHODS The expression of mesothelioma-related markers (D2-40, Cal...

PURPOSE Hypoxia in the tumor microenvironment triggers a variety of genetic and adaptive responses that regulate tumor growth. Tumor hypoxia is often associated with more malignant phenotypes, resistance to therapy, and poor survival. The purpose of this study was to evaluate the prevalence of hypoxia in meningiomas using the endogenous hypoxia marker carbonic anhydrase 9 (CA9) and to relate th...

Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome. The aim of this study was t...

Background: Complete surgical resection is the first-line therapy for meningiomas. However, tumor location and biological aggressiveness can make surgical cure impossible. Treatment options for these refractory meningiomas include further surgery, conventional external beam irradiation, stereotactic radiosurgery, and systemic therapies. In this paper, we discuss new and emerging systemic therap...