نتایج جستجو برای: m2 gene

تعداد نتایج: 1181315  

2013
Ndongo Dia Mbayame N Niang Saadiya A Diadhiou Déborah G Goudiaby Abdourahmane Faye Davy Kiori Mady Bâ Rémy Michel Ousmane M Diop

BACKGROUND Among Influenza neuraminidase inhibitors (NAIs), oseltamivir corresponds to the most widely used agent to treat influenza disease. However since 2001, several cases of resistance to NAIs have been reported for circulating seasonal A(H1N1) Influenza viruses. A direct resistance mechanism may be invoked, involving critical mutations in the viral NA gene that prevent the drug binding to...

Journal: :PLoS Pathogens 2008
Sofia Marques Marta Alenquer Philip G. Stevenson J. Pedro Simas

The pathogenesis of persistent viral infections depends critically on long-term viral loads. Yet what determines these loads is largely unknown. Here, we show that a single CD8+ T cell epitope sets the long-term latent load of a lymphotropic gamma-herpesvirus, Murid herpesvirus-4 (MuHV-4). The MuHV-4 M2 latency gene contains an H2-Kd -restricted T cell epitope, and wild-type but not M2(-) MuHV-...

1996
KEVIN M. COOMBS

A newly identified temperature-sensitive mutant whose defect was mapped to the reovirus M1 gene (minor core protein m2) was studied to better understand the functions of this virion protein. Sequence determination of the M1 gene of this mutant (tsH11.2) revealed a predicted methionine-to-threonine alteration at amino acid 399 and a change from proline to histidine at amino acid 414. The mutant ...

Journal: :Neuron 2015
Vania Yu Cao Yizhou Ye Surjeet Mastwal Ming Ren Matthew Coon Qing Liu Rui M. Costa Kuan Hong Wang

Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed that lesion or inactivation of the secondary motor (M2) cortex disrupts learning ...

Journal: :The Biochemical journal 1993
I A Khatri G G Forstner J F Forstner

In the present report we describe the isolation and sequence of a partial cDNA (M2-798) for a rat intestinal mucin designated M2. A rat intestinal lambda ZAP II cDNA library was screened using a polyclonal antiserum which was prepared against deglycosylated high-molecular-mass glycopeptides of the purified mucin. Mucin cDNA clones were found to contain tandem repeats of 18 nt which encoded a th...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده کشاورزی 1390

تنش دمای پایین یکی از مهم ترین عوامل محیطی است که عملکرد گیاهان را محدود می نماید. شبکه وسیعی از ژن های مختلف در تنظیم تحمل گیاه به این تنش نقش ایفا می نمایند. در این تحقیق، نخست 921 عدد از ژن های مذکور از تحقیقات و مقالات معتبر علمی استخراج گردید و سپس به منظور شناسایی ژن های مشابه با آنها در ژنوم کامل دو گیاه سیب (malus domestica)و انگور (vitis vinifera)، توالی آمینو اسیدی این ژن ها در گیاه م...

2014
Moses T. Bility Banchob Sripa

Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene e...

Journal: :Journal of immunology 2010
Long V Ly Aabed Baghat Mieke Versluis Ekaterina S Jordanova Gregorius P M Luyten Nico van Rooijen Thorbald van Hall Pieter A van der Velden Martine J Jager

Macrophages are part of the tumor microenvironment and have been associated with poor prognosis in uveal melanoma. We determined the presence of macrophages and their differentiation status in a murine intraocular melanoma model. Inoculation of B16F10 cells into the anterior chamber of the eye resulted in rapid tumor outgrowth. Strikingly, in aged mice, tumor progression depended on the presenc...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
P L Collins M G Hill E Camargo H Grosfeld R M Chanock B R Murphy

Infectious human respiratory syncytial virus (RSV) was produced by the intracellular coexpression of five plasmid-borne cDNAs. One cDNA encoded a complete positive-sense version of the RSV genome (corresponding to the replicative intermediate RNA or antigenome), and each of the other four encoded a separate RSV protein, namely, the major nucleocapsid N protein, the nucleocapsid P phosphoprotein...

Journal: :medical journal of islamic republic of iran 0
mojgan amirpour mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) hossein ayatollahi cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad universi-ty of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)سازمان های دیگر: cancer molecular pathology research center maryam sheikhi cancer molecular pathology research center, department of hematology and blood bank, mashhad university of medical scienc-es, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)سازمان های دیگر: cancer molecular pathology research center somaye azarkerdar mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) seyyede fatemeh shams cancer molecular pathology research center, department of hematology and blood bank, mashhad university of medical scienc-es, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)سازمان های دیگر: cancer molecular pathology research center

background: acute myeloid leukemia (aml) is known as one of the most common leukemia among adults. environmental and different genetic factors affect disease process, prognosis and treatment. among different genetic factors npm1, flt3, mll and baalc genes are the most effective on patient's survival rate. the aim of this study was to assess amount of baalc gene expression in aml patients, and i...

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