Previous studies have shown that a deficiency in DNA damage repair is associated with increased cancer risk, and exposure to UV radiation is a major risk factor for the development of malignant melanoma. High density of common nevi (moles) is a major risk factor for cutaneous melanoma. A nevus may result from a mutation in a single UV-exposed melanocyte which failed to repair DNA damage in one ...

Objective: Balance of DNA damage and proper repair plays an important role in progression of bladder cancer. Here we aimed to assess the associations of nineteen polymorphisms from seven DNA repair-associated genes (PRAP1, OGG1, APEX1, MUTYH, XRCC1, XRCC2 and XRCC3) and their interactions with bladder cancer in a Han Chinese population. Methods: A case-control study including 227 bladder cancer...

REFERENCES 1. Hammers AL, Sanchez-Ramos L, Kaunitz AM. Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. Am J Obstet Gynecol 2015;212:505.e1-13. 2. Ment LR, Ådén U, Lin A, et al. Gene-environment interactions in severe intraventricular hemorrhage of pret...

9. Nakamura M, Yamamoto H, Kikuchi Y, Ishihara Y, Sata T, Yoshimura Y: Cerebral atherosclerosis in Japanese. 1. Age related to atherosclerosis. Stroke 2: 400-408, 1971 10. Brice JG, Dowsett DJ, Lowe RD: The effect of constriction on carotid blood flow and pressure gradient. Lancet 1: 84-85, 1964 11. Hinton RC, Mohr JP, Ackerman RH, AdairLB, Fisher CM: Symptomatic middle cerebral artery stenosis...

State’s 66,511 square miles is rural. In 1994, there were 1.6 million women aged 10–49 in the state, and 17% of them lived in rural areas.5 The state has a long history of legal access to abortion, but the number of providers in rural Washington State has always been limited and has declined further in recent years. In 1983, only 10 of the state’s 28 rural counties had a provider; there were 19...

BACKGROUND There has recently been a strong interest in the inter-individual variation in normal tissue and tumor response to radiotherapy (RT), because tissue radiosensitivity seems to be under genetic control. Evidence is accumulating on the role of polymorphic genetic variants, such as single nucleotide polymorphisms (SNPs) that could influence normal tissue response after radiation. The mos...

Carcinogens present in tobacco smoke lead to several types of DNA damage in bronchial cells. In lung cancer, karyotype, allelotype, and fluorescence in situ hybridization analyses have demonstrated the common presence of aneuploidy, although its severity varies considerably among tumors. Deficiencies in the DNA-double strand break (DSB) repair system may be critical in the generation and persis...