نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

Journal: :Cancer research 2007
Takayuki Takeda Noboru Hattori Takahiro Tokuhara Yoshihiro Nishimura Mitsuhiro Yokoyama Masayuki Miyake

Conventional therapies still remain less effective for metastasis of lung cancer, thus leading to a poor prognosis for this disorder. Although the processes involved in metastasis have not yet been clearly elucidated, our previous studies have shown that higher expression levels of MRP-1/CD9 and KAI1/CD82 in cancer cells are significantly correlated with less metastatic potency. To determine wh...

2017
Xiaolong Huang Jingsong Huang Dewen Leng Shuo Yang Qi Yao Jin Sun Jun Hu

BACKGROUND Lung cancer stem cells (CSCs) are considered to be the seed of lung cancer, and CD133 is a marker of lung CSCs. Here, we developed gefitinib-loaded poly(ethylene glycol) 2000-distearoylphosphatidylethanolamine nanomicelles with CD133 aptamers (M-Gef-CD133) to eliminate CD133+ lung CSCs. METHODS M-Gef-CD133 was prepared using a lipid-film-based approach. The targeting and activity o...

Farzaneh Allaveisi Nasrin Amini Safoora Nikzad, Zeinab Salehi

Introduction: This study aims to compare the dose delivery parameters and radiobiologic model prediction of Tumor Control Probability (TCP) of the FIMRT technique compared with rectangular two tangential wedged fields (2FW) in the treatment of breast cancer. Furthermore, reduction of the heart and lung dose in the FIMRT was studied via dosimetric parameters and radiobiologic mo...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2005
K Ulrich M Stern M E Goddard J Williams J Zhu A Dewar H A Painter P K Jeffery D R Gill S C Hyde D M Geddes M Takata E W F W Alton

Alveolar type II (ATII) cell proliferation and differentiation are important mechanisms in repair following injury to the alveolar epithelium. KGF is a potent ATII cell mitogen, which has been demonstrated to be protective in a number of animal models of lung injury. We have assessed the effect of recombinant human KGF (rhKGF) and liposome-mediated KGF gene delivery in vivo and evaluated the po...

2008
Mark Copley

Two major factors affect drug delivery with nebulizers: usage time and droplet size. Unlike other inhalation devices, nebulizers provide continuous delivery instead of a pre-metered dose of drug. Once loaded and activated, a nebulizer operates with the user breathing normally so that the patient’s breathing profile and usage time determine the amount of drug received. As with other inhalation p...

2011
Arash Minai-Tehrani Young-Chan Park Soon-Kyung Hwang Jung-Taek Kwon Seung-Hee Chang Sung-Jin Park Kyeong-Nam Yu Ji-Eun Kim Ji-Young Shin Ji-Hye Kim Bitna Kang Seong-Ho Hong Myung-Haing Cho

Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can involve several approaches. Among these, aerosol gene delivery is a potentially more effective approach. In this study, Akt1 kinase-deficient (KD) and wild-type (WT) Akt1 were delivered t...

Journal: :Journal of Cystic Fibrosis 2023

Objectives: Approximately 15% of people with cystic fibrosis (pwCF) either have a pathogenic CFTR variant that is not amenable to modulator therapy or exhibit intolerance modulators. Delivery functional copy the gene airways could provide durable benefit regardless underlying variant. 4D-710 novel aerosolized genetic medicine comprising synthetic AAV vector (A101) and human deletion in regulato...

2014
Yanlin Jia Ken Chen Peihui Lin Gissela Lieber Miyuki Nishi Rosalie Yan Zhen Wang Yonggang Yao Yu Li Bryan A. Whitson Pu Duann Haichang Li Xinyu Zhou Hua Zhu Hiroshi Takeshima John C. Hunter Robbie L. McLeod Noah Weisleder Chunyu Zeng Jianjie Ma

Injury to lung epithelial cells has a role in multiple lung diseases. We previously identified mitsugumin 53 (MG53) as a component of the cell membrane repair machinery in striated muscle cells. Here we show that MG53 also has a physiological role in the lung and may be used as a treatment in animal models of acute lung injury. Mice lacking MG53 show increased susceptibility to ischaemia-reperf...

Journal: :journal of paramedical sciences 0
afshin khavari department of hepatitis and aids, pasteur institute of iran, tehran, iran zahra orafa department of hepatitis and aids, pasteur institute of iran, tehran, iran mehrdad hashemi department of genetics, islamic azad university, tehran medical sciences branch,tehran,iran noorieh habibzadeh department of hepatitis and aids, pasteur institute of iran, tehran, iran azam bolhassani department of hepatitis and aids, pasteur institute of iran, tehran, iran

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Journal: :journal of family and reproductive health 0
housne begum institute of health economics, university of dhaka, dhaka, bangladesh amir mohammad sayem bangladesh institute of social research (bisr), dhaka, bangladesh nilufar nili officer on special duty (medical officer), directorate general of health services, mohakhali, dhaka,

objective: this study focused on the factors affecting the institutional delivery and delivery assisted by health professionals in urban slums. materials and methods: a semi-structured questionnaire was developed to collect information from women aged 15-49 who had at least one birth. totally 540 eligible women were interviewed. results: the results showed that around 20% of women delivered at ...

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