نتایج جستجو برای: lung delivery
تعداد نتایج: 508290 فیلتر نتایج به سال:
Conventional therapies still remain less effective for metastasis of lung cancer, thus leading to a poor prognosis for this disorder. Although the processes involved in metastasis have not yet been clearly elucidated, our previous studies have shown that higher expression levels of MRP-1/CD9 and KAI1/CD82 in cancer cells are significantly correlated with less metastatic potency. To determine wh...
BACKGROUND Lung cancer stem cells (CSCs) are considered to be the seed of lung cancer, and CD133 is a marker of lung CSCs. Here, we developed gefitinib-loaded poly(ethylene glycol) 2000-distearoylphosphatidylethanolamine nanomicelles with CD133 aptamers (M-Gef-CD133) to eliminate CD133+ lung CSCs. METHODS M-Gef-CD133 was prepared using a lipid-film-based approach. The targeting and activity o...
Introduction: This study aims to compare the dose delivery parameters and radiobiologic model prediction of Tumor Control Probability (TCP) of the FIMRT technique compared with rectangular two tangential wedged fields (2FW) in the treatment of breast cancer. Furthermore, reduction of the heart and lung dose in the FIMRT was studied via dosimetric parameters and radiobiologic mo...
Alveolar type II (ATII) cell proliferation and differentiation are important mechanisms in repair following injury to the alveolar epithelium. KGF is a potent ATII cell mitogen, which has been demonstrated to be protective in a number of animal models of lung injury. We have assessed the effect of recombinant human KGF (rhKGF) and liposome-mediated KGF gene delivery in vivo and evaluated the po...
Two major factors affect drug delivery with nebulizers: usage time and droplet size. Unlike other inhalation devices, nebulizers provide continuous delivery instead of a pre-metered dose of drug. Once loaded and activated, a nebulizer operates with the user breathing normally so that the patient’s breathing profile and usage time determine the amount of drug received. As with other inhalation p...
Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can involve several approaches. Among these, aerosol gene delivery is a potentially more effective approach. In this study, Akt1 kinase-deficient (KD) and wild-type (WT) Akt1 were delivered t...
Objectives: Approximately 15% of people with cystic fibrosis (pwCF) either have a pathogenic CFTR variant that is not amenable to modulator therapy or exhibit intolerance modulators. Delivery functional copy the gene airways could provide durable benefit regardless underlying variant. 4D-710 novel aerosolized genetic medicine comprising synthetic AAV vector (A101) and human deletion in regulato...
Injury to lung epithelial cells has a role in multiple lung diseases. We previously identified mitsugumin 53 (MG53) as a component of the cell membrane repair machinery in striated muscle cells. Here we show that MG53 also has a physiological role in the lung and may be used as a treatment in animal models of acute lung injury. Mice lacking MG53 show increased susceptibility to ischaemia-reperf...
delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...
objective: this study focused on the factors affecting the institutional delivery and delivery assisted by health professionals in urban slums. materials and methods: a semi-structured questionnaire was developed to collect information from women aged 15-49 who had at least one birth. totally 540 eligible women were interviewed. results: the results showed that around 20% of women delivered at ...
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