background the hepatitis b virus x (hbx) protein has long been recognized as an important transcriptional transactivator of several genes. human aldo-keto reductase family 1, member c1 (akr1c1), a member of the family of akr1cs, is significantly increased in hbx-expressed cells. objectives this study aimed to investigate the possible mechanism of hbx in regulating akr1c1 expression in hepg2.2.1...

objective: breast cancer is one of the most common malignancies in women worldwide. it is caused by a number of genetic and epigenetic factors. aberrant hypermethylation of the promoter regions in specific genes is a key event in the formation and progression of breast cancers as well as the dbc2 gene, as a tumor suppressor gene. different studies show that the dbc2 gene is inactivated through ...

background & objective: interleukin (il)-10 is an important anti-inflammatory and immunomodulatory cytokine. some authors believe that single nucleotide polymorphisms (snp) in the promoter region of the il-10 gene have been associated with susceptibility to hiv infection and progression to aids, but its role is not clearly defined yet. the present study was undertaken to evaluate the associ...

background and objective: the dbc2 (deleted in breast cancer 2) or rhobtb2 (located on 8p21) is a tumor suppressor gene associated with tumorigenesis. mutational studies of dbc2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. epigenetic changes through hypermethylation of the promoter can cause the inactivation of dbc...

Abstract Background Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating miR-376c-3p/DNM3 axis. However, regulation mechanism expression in PTC is still unclear. Methods The luciferase reporter ChIP assays were used to confirm binding LEF-1 putative promoter site gene. RNA immunoprecipitation pulldown ...

the present study was performed to analyze some of the preventive vs. promoter factors of applying blended learning system in agricultural higher education as viewed from the perspective of khuzestan province's faculties of agriculture and natural resources' faculty members. statistical population of the study consisted of the members of agriculture and natural resources state college...

identification of associated genes with energy balance, yield and feed intake are recent interests of the animal breeding researchers. najdi breed is the famous cattle breed in the khuzestan province. in this research for the investigation of leptin gene promoter ,from 15 najdi cows in the shushtar cattle center station was taken. dna from whole blood was extracted and 544bp and 566 bp two piec...

congenital factor xiii deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in sistan and baluchestan province of iran. the discovery of promoter hypermethylation of numerous mirnas in human diseases has demonstrated an epigenetic mechanism for aberrant mirna expression. the present study has analyzed methylation and expression stat...