Renovascular occlusive lesions account for the most common form of surgically correctable hypertension. Technical advances in vascular reconstructive surgery have increased the likelihood of renal parenchymal preservation and amelioration of hypertension in patients having renal artery stenoses. Proper selection of patients alleged to have renovascular hypertension for operative treatment is th...

The present study assessed the contribution of the renin-angiotensln system (RAS), dietary sodium, and cardiac output (CO) to the genesis of primate hypertension in a one-kidney model which was developed to test species-specific renin inhibitors. Reduction of renal perfusion pressure increased mean arterial pressure (MAP) from 105 ± 4 to 127 ± 3 mm Hg (p < 0.0005), associated with increased pla...

The present study assessed the contribution of the renin-angiotensln system (RAS), dietary sodium, and cardiac output (CO) to the genesis of primate hypertension in a one-kidney model which was developed to test species-specific renin inhibitors. Reduction of renal perfusion pressure increased mean arterial pressure (MAP) from 105 ± 4 to 127 ± 3 mm Hg (p < 0.0005), associated with increased pla...

Fifty years ago, investigators identified renin inhibition as the preferred pharmacologic approach to blockade of the renin-angiotensin system. Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. Until very recentl...

Although high-fat and high-salt diets are considered risk factors for hypertension, the intake of salty soybean-based fermented foods has beneficial effects. This study explored potential Chinese traditional soy sauce (CTFSS) in preventing hypertension by analyzing its effects on adipogenesis renin-angiotensin-aldosterone system (RAAS). Male Sprague-Dawley (SD) rats were divided into four group...

Renal pressor activity was measured in rats with the different types of experimental hypertension using a direct method for the evaluation of the role of the renal pressor material in the production and the maintenance of high blood pressure. Renin content was increased in the constricted kidney and decreased in the contralateral of renal hypertension, and also decreased in adrenal regeneration...

Letter by Zhou and Zhou Regarding Article, “Hypertension: Renin–Angiotensin– Aldosterone System Alterations” To the Editor: Activation of the renin–angiotensin–aldosterone system (RAAS) is believed to play an important role in hypertension. However, although having a higher risk of hypertension, blacks exhibit lower plasma renin levels compared with whites. Moreover, black hypertensives show an...

Letter by Zhou and Zhou Regarding Article, “Hypertension: Renin–Angiotensin– Aldosterone System Alterations” To the Editor: Activation of the renin–angiotensin–aldosterone system (RAAS) is believed to play an important role in hypertension. However, although having a higher risk of hypertension, blacks exhibit lower plasma renin levels compared with whites. Moreover, black hypertensives show an...

1. Using a newly developed and validated radioassay method, we have measured plasma 11-deoxycorticosterone concentrations in a wide spectrum of human hypertensive states. 2. Patients with essential and renovascular hypertension have normal plasma concentrations of 11-deoxycorticosterone. 3. Elevated concentrations are seen in some patients with primary aldosteronism, Cushing's syndrome, low-ren...