Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty...

this study is an attempt at a colonial and postcolonial reading of joseph conrad’s lord jim. it is specifically focused on the narrative strategies used in the novel. in other words, it investigates the connection between the narrative strategy and a possible tone of imperialism in conrad’s novel. for the introduction, a brief review of conrad’s manner of writing and his peculiar ambiguity is p...

Lord Rabbi Sacks was a major religious Jewish figure. In this article, we examine his version of covenant-based communitarianism. We begin with exploring Sacks’ social communitarian view, and support politics. then turn to evaluate argue that while view is valuable important, political faces the same challenges troubled views, namely fact religious, value, ethnic plurality. One possible way for...

squalid houses commanding even the most distant view of the proceedings were full of boys and girls anxious to catch a glimpse of the Prince. His Royal Highness, who passed to the platform amid terrific cheering, was accompanied by various officials of Guy's, and took his seat between Lord Goschen, the Treasurer of the Hospital, and Mr. Herbert Waring, Vice-Chancellor of the University of Londo...

1. “LAUDATO SI’, mi’ Signore” – “Praise be to you, my Lord”. In the words of this beautiful canticle, Saint Francis of Assisi reminds us that our common home is like a sister with whom we share our life and a beautiful mother who opens her arms to embrace us. “Praise be to you, my Lord, through our Sister, Mother Earth, who sustains and governs us, and who produces various fruit with coloured f...

OBJECTIVES To examine the reliability and validity of the Clock Drawing Test when used as a cognitive screening instrument for mild to moderate dementia, and to compare different scoring mechanisms. DESIGN Retrospective analysis of clock drawing performance using three published scoring methods (Shulman, Sunderland and Wolf-Klein). SETTING Hospital-based memory disorders clinic. PARTICIPA...

Abstract We define and develop two-level type theory (2LTT), a version of Martin-Löf which combines two different theories. refer to them as the ‘inner’ ‘outer’ theory. In our case interest, inner is homotopy (HoTT) may include univalent universes higher inductive types. The outer traditional form validating uniqueness identity proofs (UIP). One point view on it internalised meta-theory There a...