Systematic reviews and meta-analysis have demonstrated an improved prognosis by chemotherapy of malignant glioma patients. The effects of clinical research therefore have the aim to find more active drugs or new combination therapies. The combination of Temozolomide (TMZ) and nitrosoureas was evaluated preclinically with an evidence of therapeutic synergy. Based on these findings, we have carri...

1 Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia 2 Baker IDI Heart and Diabetes Institute, Melbourne, Australia 3 Department of Pharmacology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia 4Department of Internal and Agri...

Interference of oncogenic N-nitrosourea in intraocular tumor induction by human adenovirus type 12 in rats was examined. Transplacental administration of methylnitrosourea to rat embryo reduced significantly the latent period of the intraocular adenovirus tumor in each animal whereas in groups preadministered with ethylnitrosourea the decrease in the latent period showed marked individual varia...

The view is explained that the ongoing conflict between Industry, public authorities and other interested groups on the evaluation of risks and benefits of biotechnology can not be reduced only to a matter of missing factual scientific, legal or economic information. Analyses conducted inside and outside Commission services suggest that there is not the clear correlation between knowledge and a...

BACKGROUND "Clinical ethics consultation" (CEC) is the provision of consultative services by an individual or team with the aim of helping health professionals, patients, and their families grapple with difficult ethical issues arising during health care. There are almost 25,000 articles in the worldwide literature on CEC, but very few explicitly address measuring the quality of CEC. Many more ...

1 Mater Research Institute, University of Queensland, Brisbane, QLD, Australia 2 School of Medicine, University of Queensland, Brisbane, QLD, Australia 3 Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia 4 Department of Immunology, Monash University, Melbourne, VIC, Australia 5 School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia *Correspon...