This paper deals with a capacitated hub location problem arising in the design of telecommunications networks. The problem is different from the classical hub location problem in two ways: the cost of using an edge is not linear but stepwise and the capacity of an hub restricts the amount of traffic transiting through the hub rather than the incoming traffic. In this paper both an exact and a h...

The ability of germ cells to carry out a gene regulatory program distinct from the surrounding somatic tissue, and their capacity to specify an entire new organism has made them a focus of many studies that seek to understand how specific regulatory mechanisms, particularly post-transcriptional mechanisms, contribute to cell fate. In zebrafish, germ cells are specified through the inheritance o...

Germ-line stem cells (GSCs) are maintained by the somatic microenvironment, or GSC niche, which ensures that GSCs can both self-renew and produce functional gametes. However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells that form the GSC niche are derived from a subset of somatic gonadal precursors ...

OBJECTIVE Factors influencing long-term viability of an intermediated regional food supply network (food hub) were modeled using agent-based modeling techniques informed by interview data gathered from food hub participants. BACKGROUND Previous analyses of food hub dynamics focused primarily on financial drivers rather than social factors and have not used mathematical models. METHOD Based ...

in this paper, a hierarchical p-hub median problem is considered that all the nodes and arcs on the network have limited capacities. proposed model has three-level where the complete network at the top level consists of the central hubs. the second and third levels consist of hub and demand nodes respectively, which are connected through star networks. also, delivery time restriction is taken i...

The third Heidelberg Unseminars in Bioinformatics (HUB) was held on 18th October 2012, at Heidelberg University, Germany. HUB brought together around 40 bioinformaticians from academia and industry to discuss the 'Biggest Challenges in Bioinformatics' in a 'World Café' style event.

We investigate the economic hubs and authorities of the world trade network (WTN) from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS) algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with ...

The objective of this study was to identify hub genes and pathways associated with hepatocellular carcinoma (HCC) by centrality analysis of a co-expression network. A co-expression network based on differentially expressed (DE) genes of HCC was constructed using the Differentially Co-expressed Genes and Links (DCGL) package. Centrality analyses, for centrality of degree, clustering coefficient,...

Abstract. Given the demand between each origin-destination pair on a network, the planar hub location problem is to locate the multiple hubs anywhere on the plane and to assign the traffic to them so as to minimize the total travelling cost. The trips between any two points can be nonstop (no hubs used) or started by visiting any of the hubs. The travel cost between hubs is discounted with a fa...

To resolve the difficulties in deployment of the classic security solution S-BGP (Secure Border Gateway Protocol), the Translator Trust Model (TTM) for a new solution SE-BGP (Security Enhanced BGP) was proposed to transform the centralized deployment mode of S-BGP to distributed mode. However, the trust (attestations of routing information) translation of TTM only depends on a single hub node a...