The limit of detection (LOD) for any analytical procedure, the point at which analysis is just feasible, may be determined by a statistical approach based on measuring replicate blank (negative) samples or by an empirical approach, consisting of measuring progressively more dilute concentrations of analyte. The limit of quantitation (LOQ), or concentration at which quantitative results can be r...

[email protected] ABSTRACT Expert search and profiling systems aim to identify candidate experts and rank them with respect to their estimated expertise on a given topic, using available evidence. Traditional expert search and profiling systems exploit structured data from closed systems (e.g. email program) or unstructured data from open systems (e.g. the Web). However, on toda...

The Linked Open Data (LOD) cloud changes frequently. Recent approaches focus mainly on quantifying the changes that occur in the LOD cloud by comparing two snapshots of a linked dataset captured at two different points in time. These change metrics are able to measure absolute changes between these two snapshots. However, they cannot determine the dynamics of a dataset over a period of time, i....

The Linked Open Data (LOD) cloud is rapidly becoming the largest interconnected source of structured data on diverse domains. The potential of the LOD cloud is enormous, ranging from solving challenging AI issues such as open domain question answering to automated knowledge discovery. However, due to an inherent distributed nature of LOD and a growing number of ontologies and vocabularies used ...

Background: Currently clomiphene citrate is the first-line treatment to induce ovulation in women with polycystic ovarian syndrome (PCOS). Surgical therapy with laparoscopic ovarian drilling (LOD) may avoid or reduce the need for gonadotropins. Objective: To determine the effectiveness and safety of LOD compared with ovulation induction in subfertile women with clomiphene-resistant PCOS. Search...

For complex diseases, underlying etiologic heterogeneity may reduce power to detect linkage. Thus, methods to identify more homogeneous subgroups within a given sample in a linkage study may improve detection of putative susceptibility loci. In this study we describe an ordered subsetting approach that utilizes disease-related quantitative trait data to complement traditional linkage analysis. ...

CHOREO: Ron & Georgine Woolcock, 5326 Berger Dr SE, Olympia, WA 98513 TELEPHONE: 360-456-2056 E-MAIL: [email protected] MUSIC: “If I Had To Do It All Over Again” by Roy Clark, Varese Vintage CD “Roy Clark Greatest Hits” Track 13. D/L available from Internet. RHYTHM: Two Step PHASE: II TIME/SPEED: 2:37/100% FOOTWORK: Opposite, directions for man except where noted. DATE: June, 2007 SEQUENCE...

BACKGROUND Autism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been carried out to identify regions harboring genes related to autism or autism spectrum disorders, with mixed results. Given the overlap in autism features with genetic abnormalities known to be associated with imprinting, one possible reason for la...

Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (Screening Set 11) were genotyped. Quantitative linkage analyses were performed...

Pulse pressure, the difference between systolic and diastolic blood pressure, is an independent risk factor for cardiovascular disease. Increased pulse pressure reflects reduced compliance of arteries and is a marker of atherosclerosis. To locate genes that affect pulse pressure, a genome-wide linkage scan for quantitative trait loci influencing pulse pressure was performed using variance compo...