Results Data were available on 44 children. 81.8% were female and 88.6% were Caucasian, of which 13.6% were Latino. Mean age at onset was 8.2 years (± 4.0), yet first evaluation by a pediatric rheumatologist was 9.9 years (± 4.2). Reported subtypes were: 34 linear scleroderma (LiScl: 25 trunk/limbs, 9 face/neck), 7 with circumscribed morphea (CM: 5 deep, 2 superficial), 6 with generalized morph...

Morphea or localized scleroderma is a distinctive inflammatory disease that leads to sclerosis of the skin and subcutaneous tissues. It comprises a number of subtypes differentiated according to their clinical presentation and the structure of the skin and underlying tissues involved in the fibrotic process. However, classification is difficult because the boundaries between the different types...

Linear scleroderma is a connective tissue disorder that characteristically involves the skin. Skin induration and pigmentary changes present in a linear distribution. Severe functional and cosmetic disability may occur, especially in growing children. No effective therapy for the fibrotic stage of scleroderma is available at present. Recently a beneficial effect of oral 1, 25-dihydroxyvitamin D...

Lichen sclerosus et atrophicus and limited systemic scleroderma (acrosclerosis) are inflammatory skin diseases that ultimately evolve into two distinct modes of atrophic scar formation, but which can easily be confused clinically. They are very rarely associated. The literature has reported cases in which lichen sclerosus was associated with various forms of scleroderma, but often with localize...

Of those things that can be estimated well in an inverse problem, which are best to estimate? Backus-Gilbert resolution theory answers a version of this question for linear (or linearized) inverse problems in Hilbert spaces with additive zero-mean errors with known, finite covariance, and no constraints on the unknown other than the data. This paper extends Backus-Gilbert resolution: it defines...

There has been a significant interest on plasmonics in a metallic structure with very narrow gaps for studies of nanophotonics. However, little attention has been paid to the behavior of surface plasmons (SPs) in quasi-continuous metallic structures. This study observes and analyzes intermediate characteristics between propagating SPs (PSPs) and localized SPs (LSPs) in a quasi-continuous metall...

Effects of a toroidal rotation are investigated numerically on the stability of the MHD modes in the edge pedestal, which relate to the type-I edge-localized mode (ELM). A new linear MHD stability code MINERVA is developed for solving the Frieman-Rotenberg equation, which is the linear ideal MHD equation with flow. As the result of the stability analysis, it is revealed that the sheared toroida...

The evolution of edge pedestal parameters between edge-localized modes (ELMs) is analyzed for an H-mode DIII-D [J Luxon, Nucl. Fusion 42, 612 (2002)] discharge. Experimental data are averaged over the same sub-intervals between successive ELMs to develop data that characterize the evolution of density, temperature, rotation velocities, etc. over the interval between ELMs. These data are interpr...

Parry-Romberg syndrome or progressive facial hemiatrophy was first described by Caleb Parry in 1825 and Moritz Romberg in 1846. This disorder is characterized by slowly progressing acquired unilateral hemifacial atrophy, which affects subcutaneous tissue together with the muscles and underlying bones. The pathogenesis and precise incidence of the syndrome remain unclear. Immune-mediated process...

INTRODUCTION Morphea is an inflammatory skin disorder characterized by excessive collagen deposition. Although treatment algorithms for morphea subtypes have been suggested, no consistent recommendations are available. This study attempts to evaluate the clinical efficacy of methotrexate (MTX) as monotherapy in refractory generalized morphea. METHODS It is a retrospective study, including 20 ...