BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH) causes high morbidity and mortality. Recently, perihemorrhagic edema (PHE) has been suggested as an important prognostic factor. Therapeutic hypothermia may be a promising therapeutic option to treat PHE. However, no data exist about the optimal timing and duration of therapeutic hypothermia in ICH. We examined the impact of therapeutic hypo...

In recent years, there has been increasing interest in hypothermia induced by paracetamol for therapeutic purposes, which, in some instances, has been reported as a side effect. Understanding the mechanism by which paracetamol induces hypothermia is therefore an important question. In this study, we investigated whether the novel metabolite of paracetamol, N-(4-hydroxyphenyl)arachidonylamide (A...

OBJECTIVE Neuroprotection by hypothermia has been an important research topic over last two decades. In animal models of spinal cord injury, the primary focus has been assessing the effects of hypothermia on behavioral and histologic outcomes. Although a few studies have investigated electrophysiological changes in descending motor pathways with motor-evoked potentials recorded during cooling, ...

conclusions body temperature changes in human poisonings are a matter in need of special attention. a literature review did not reveal any controversy over hypothermia, but poisoning cases exhibit a variety of patterns of fever and hyperthermia. if there are no limits to the diagnosis of fever and hyperthermia, all cases with a poor prognosis which fail to respond to treatment could be categori...

conclusions results of this study indicate that selective brain cooling is an effective method of decreasing icp in rats; however, the deeper hypothermia caused a greater decrease in icp three hours after hypothermia induction. background experimental approaches have been promising with the use of therapeutic hypothermia after traumatic brain injury (tbi) whereas clinical data have not supporte...

Hand implantation surgery is always on an urgent basis and lasts for many hours. Simple, safe and reliable anaesthesia would be necessary and many types of anaesthetic techniques have been advocated. General anaesthesia is effective, but there are problems associated with a prolonged general anaesthesia with an increase in the incidence of hypothermia, accidental intraoperative awareness and a ...

Human exposure to cold and heat stimulates cutaneous vasoconstriction and vasodilation via distinct sympathetic reflex and locally mediated pathways. The mechanisms mediating cutaneous vasoconstriction and vasodilation are impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness, respectively. This paper highlights...

background: asphyxia is a perinatal accident with a high mortality rate, therapeutic hypothermia in both head or whole body was suggested as effective therapeutic methods. in this study, we compare these methods in neonates with asphyxia.methods and materials: 16 neonates with asphyxia in two hospitals including alzahra(head hypothermia) and taleghani hospital (total body hypothermia) went unde...

This study was designed to reveal the therapeutic regimen and mechanism of action underlying hypothermia treatment in combination with stem cell transplantation for ameliorating neonatal hypoxic-ischemic-like injury. Primary rat neurons were exposed to oxygen-glucose deprivation (OGD), which produced hypoxic-ischemic-like injury in vitro, then incubated at 25°C (severe hypothermia), 34°C (moder...