PURPOSE AND EXPERIMENTAL DESIGN To assess the prognostic significance of intratumoral aromatase in endometrioid endometrial cancer, sections from 55 patients with endometrial cancer were evaluated for expression of aromatase using immunohistochemistry, and the correlation between aromatase expression and clinicopathologic parameters were analyzed. RESULTS Immunohistochemical staining for arom...

BACKGROUND/PURPOSE Endometrial hyperplasia is considered a precursor of endometrial carcinoma, but concurrent endometrial carcinoma in patients with endometrial hyperplasia is seen frequently. Our aim was to examine the risk factors for coexisting endometrial carcinoma in patients with endometrial hyperplasia. METHODS Between January 1996 and September 2006, 77 patients who underwent hysterec...

Our objective was to investigate the first-pass effect to the uterus of progesterone gel administered vaginally. This was a prospective, randomized study of 32 postmenopausal women, attending our menopause clinic. All women used transdermal estradiol (50 microg/day, a patch each week) for 2 weeks. They used either vaginal progesterone gel or intramuscular progesterone in oil 50 mg after 24 h to...

Background Endometrial receptivity is one of parameters which determine the reproductive outcome in in vitro fertilization programs. A good blood supply towards the endometrium is usually considered to be an essential requirement for implantation. Blood vessels of the endometrium can be detected by transvaginal color and pulse Doppler sonography. Color Doppler assessment permits better visualiz...

Endometrial carcinoma is the second commonest gynaecological malignancy. Survival is generally better than with other genitourinary malignancies on account of its overt presentation with postmenopausal bleeding and its tendency for local progression as opposed to early systemic dissemination. Consequently, surgery is the gold standard therapeutic strategy, and to date there is little evidence t...

A previously healthy 28-year-old G1P1 Asian woman presented with a 1-year history of a painful palpable lesion arising within the left perineum. Histopathology revealed multiple endometriotic foci composed of endometrial glands and moderate dense stroma, surrounded by dense fibro-elastic tissue. This patient was diagnosed as endometriosis and the endometriotic mass was excised under local anaes...

endometrial cancer generally carries a good prognosis. endometrial carcinoma more frequently metastasizes to the pelvic and para-aortic nodes. visceral metastases usually occur in the vagina and ovaries. distant metastases involve lungs and occur as a terminal event. this case report describes vulvalar metastasis of endometrial cancer to the clitoris. metastatic tumors of the vulva are rare. mo...

background: reviewing the literature reveals that pentoxifylline (ptx) plus tocopherol (vitamin e) are used mainly to promote sperm quality. however trials focusing on the effects of these drugs in female partner are limited. combination of pentoxifylline and vitamin e appeared to improve the pregnancy rate in patients with a thin endometrium by increasing the endometrial thickness and improvin...

Background: Endometrial hyperplasia is important clinically, because it can lead to abnormal uterine bleeding (AUB) which itself can precede to endometrial cancer. Endometrial carcinoma is the most common malignancy of the female genital tract, occurring about 75-85% in younger, perimenopousal women as hyperplasic endometrial. The treatment is hysterectomy or hormone therapy with progesterone. ...

BACKGROUND Treatment of recurrent gynecologic cancer is a challenging issue. Aim of the study was to investigate clinical features and outcomes of patients with recurrent gynecologic malignancies who underwent resection including IOERT (intraoperative electron radiation therapy) with regard to clinical outcome and potential predictive factors or subgroups that benefit most from this radical tre...