Doxorubicin (DOX) and Pluronic-PAA interaction was investigated using isothermal titration calorimetry (ITC). DOX/polymer interaction is governed primarily by electrostatic interaction. The uptake of DOX results in the formation of insoluble polymer/DOX complex. Addition of salt weakens the interaction of drug and polymer by charge shielding effect between positive ionized amino group on DOX an...

This report is the result of a research project on a pavement management system that was preformed by the Transportation Division of Iran University of Science and Technology. Information used in the project was collected from 20 zones of the Tehran Municipality. Any maintenance and repair system for roads is normally compared of a number of general and coordinated activities in conjunction wit...

BACKGROUND Glenoid component survival is critical to good long-term outcomes in total shoulder arthroplasty. Optimizing the fixation environment is paramount. The purpose of this study was to compare two glenoid cementing techniques for fixation in total shoulder arthroplasty. METHODS Sixteen cadaveric specimens were randomized to receive peg-only cementation (CPEG) or full back-side cementat...

We present a multiscale model for numerical simulations of dynamics of crystalline solids. The method combines the continuum nonlinear elasto-dynamics model, which models the stress waves and physical loading conditions, and molecular dynamics model, which provides the nonlinear constitutive relation and resolves the atomic structures near local defects. The coupling of the two models is achiev...

Background Knee osteoarthritis is a debilitating condition and increased dynamic loading at the knee has been linked with increased progression of the disease. Lateral wedge insoles have been used in clinical practice since the late 1980s. It is theorised that lateral wedge insoles increase the subtalar joint valgus orientation and increase the ankle valgus moment [1], with subsequent reduced k...

The analysis of the human grasping and manipulation capabilities is paramount for investigating human sensory-motor control and developing prosthetic and robotic hands resembling the human ones. A viable solution to perform this analysis is to develop instrumented objects measuring the interaction forces with the hand. In this context, the performance of the sensors embedded in the objects is c...

plug-flow digesters with periodic loading mechanism are more enthusiastic than fully mechanized digestion plants for the majority of small or medium scale farms according to the costs and operational complexities. a dual-compartment plug-flow reactor equipped with a passive heating system was designed and experimentally operated by purpose of demonstrating a simple and low cost technology for ...

Original scientific paper Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analy...

A novel biomass composite inspired from wood porous structure was manufactured by impregnating vinyl monomer into wood cellular structure under vacuum conditions, and initiating the monomer for in situ polymerization through a thermal treatment. The vacuum condition was studied, and the mechanical properties of the composite were also tested. SEM observation shows that polymer generated in the ...