نتایج جستجو برای: lncrna

تعداد نتایج: 6925  

2016
Yong‐Tao Yang Yu‐Fan Wang Ju‐Yi Lai Shi‐Yue Shen Feng Wang Jie Kong Wei Zhang Hong‐Yu Yang

With the development of functional genomics studies, a mass of long non-coding RNAs (LncRNA) were discovered from the human genome. Long non-coding RNAs serve as pivotal regulators of genes that are able to generate LncRNA-binding protein complexes to modulate a great number of genes. Recently, the LncRNA urothelial carcinoma-associated 1 (UCA1) has been revealed to be dysregulated, which plays...

2016
Yanting Liu Ningbo Xu Boyang Liu Yiru Huang Huijun Zeng Zhao Yang Zhenyan He Hongbo Guo

Resistance to temolozomide (TMZ), the standard chemotherapy agent for treating glioblastomas (GBM), is a major clinical problem for patients with GBM. Recently, long noncoding RNAs (lncRNAs) have been implicated in chemotherapy resistance in various cancers. In this study, we found that the level of the lncRNA RP11-838N2.4 was lower in TMZ-resistant GBM cells (U87TR, U251TR) compared to the par...

2017
Qian Wang Zhi-Xiao Li Bao-Wen Liu Zhi-Gang He Cheng Liu Min Chen San-Guang Liu Wei-Zhong Wu Hong-Bing Xiang

The spinal origin of jaundice-induced altered peripheral nociceptive response poorly understood. In the current study, we aimed to first validate rats with bile duct ligation (BDL) as a jaundice model accompanied by altered peripheral nociceptive response, and then to analyze differential gene and lncRNA expression patterns in the lower thoracic spinal cord on different time courses after BDL o...

2016
Meng Zhou Zhiyong Diao Xiaolong Yue Yang Chen Hengqiang Zhao Liang Cheng Jie Sun

It is increasing evidence that ceRNA activity of long non-coding RNAs (lncRNAs) played critical roles in both normal physiology and tumorigenesis. However, functional roles and regulatory mechanisms of lncRNAs as ceRNAs in pancreatic ductal adenocarcinoma (PDAC), and their potential implications for early diagnosis remain unclear. In this study, we performed a genome-wide analysis to investigat...

2015
Yongsheng Li Juan Chen Jinwen Zhang Zishan Wang Tingting Shao Chunjie Jiang Juan Xu Xia Li

Long non-coding RNAs (lncRNAs) play key roles in diverse biological processes. Moreover, the development and progression of cancer often involves the combined actions of several lncRNAs. Here we propose a multi-step method for constructing lncRNA-lncRNA functional synergistic networks (LFSNs) through co-regulation of functional modules having three features: common coexpressed genes of lncRNA p...

Journal: :International journal of oncology 2015
Xuebing Liang Lin Ma Xiao Long Xiaojun Wang

Keloid is a type of pathological skin scar. Pathogenesis of keloid is complex and is not fully understood. lncRNA can regulate gene expression on different levels. It also participates in cell cycle regulation and cell proliferation. The present study investigated the potential biological function of lncRNA in keloid. We identified differential expression of lncRNAs and mRNAs between 3 pairs of...

2015
Feng Zhi Qiang Wang Lian Xue Naiyuan Shao Rong Wang Danni Deng Suinuan Wang Xiwei Xia Yilin Yang Vinod Scaria

Long noncoding RNAs (lncRNAs) are pervasively transcribed and play a key role in tumorigenesis. The aim of the study was to determine the lncRNA expression profile in astrocytomas and to assess its potential clinical value. We performed a three-step analysis to establish the lncRNA profile for astrocytoma: a) the lncRNA expression was examined on 3 astrocytomas as well as 3 NATs (normal adjacen...

2016
Sujit Nair

In recent times, the role(s) of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in the pathogenesis of various cancers has received great attention. Indeed, there is also a growing recognition of regulatory RNA cross-talk, i.e., lncRNA-miRNA interactions, that may modulate various events in carcinogenesis and progression to metastasis. This review summarizes current evidence in the literat...

Journal: :Carcinogenesis 2011
Guangfu Jin Jielin Sun Sarah D Isaacs Kathleen E Wiley Seong-Tae Kim Lisa W Chu Zheng Zhang Hui Zhao Siqun Lilly Zheng William B Isaacs Jianfeng Xu

Long non-coding RNAs (lncRNAs), representing a large proportion of non-coding transcripts across the human genome, are evolutionally conserved and biologically functional. At least one-third of the phenotype-related loci identified by genome-wide association studies (GWAS) are mapped to non-coding intervals. However, the relationships between phenotype-related loci and lncRNAs are largely unkno...

2016
Chao Song Jian Zhang Yan Liu Hao Pan Han-ping Qi Yong-gang Cao Jian-mei Zhao Shang Li Jing Guo Hong-li Sun Chun-quan Li

Cardiac hypertrophy (CH) could increase cardiac after-load and lead to heart failure. Recent studies have suggested that long non-coding RNA (lncRNA) played a crucial role in the process of the cardiac hypertrophy, such as Mhrt, TERMINATOR. Some studies have further found a new interacting mechanism, competitive endogenous RNA (ceRNA), of which lncRNA could interact with micro-RNAs (miRNA) and ...

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