A low-power 435-MHz single-ended low-noise amplifier was implemented in a 0.35-μm silicon on insulator (SOI) CMOS technology. The SOI CMOS LNA has a simulated noise figure of 0.6 dB, input 1-dB compression point of –12.5 dBm, input thirdorder intercept point of –5 dBm, and small-signal gain of 22 dB. Total power dissipation is 10 mW from a 2.5-V supply. LNA chip area is 1.4 mm x 0.58 mm. Due to...

A highly linear Low Noise Amplifier (LNA) using a flexible feedforward linearisation scheme is described. The wideband LNA is designed for use in the frequency spectrum between 1 and 2GHz. It has a tuneable linearity profile which allows it to be adjusted for wideband moderate linearity or narrowband high linearity. The linearity can be tuned so a wideband Third Order Intercept Point (IP3) impr...

BACKGROUND The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates the degradation of hepatic low density lipoprotein receptor (LDLR) and low levels of hepatic PCSK9 activity are associated with reduced...

Hybrid nucleotide-lipids containing locked nucleic acid (LNA) show enhanced hybridization properties with complementary single strand RNAs compared to DNA lipid analogues. The LNA adenosine lipid features unique binding properties with a high binding affinity for poly-uridine and the entropically driven formation of a stable complex (K(d) ≈ 43 nM). Enhanced hybridization properties of LNA-based...

Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as beta-D-2'-O,4'-C methylene-bridged ribofuranose or other sugar derivatives in LNA analogues. The beta-D-2'-O,4'-C methylene ribofuranose LNAs in particular possess high stability and melting temperatures, which makes them of interest for stabilizing the structure of different nucleic acids. Aptamers, w...

BACKGROUND Locked nucleic acid (LNA) and 2'-O-methyl nucleic acid (OMeNA) are two of the most extensively studied nucleotide derivatives in the last decades. However, how they affect DNA quadruplex structures remains largely unknown. To explore their possible biological affinities for quadruplexes, we investigated how LNA- or OMeNA-substitutions affect G-quadruplex structure formation using a t...

Tracer amounts of either [1-14C]linolenic (18:3n-3, LNA), or [1-14C]linoleic (18:2n-6, LA) acids were intracranially injected into 19- to 20-day-old rat fetuses, and the time course of the in vivo formation and esterification of their long chain polyenoic metabolites was determined for up to 20 h. A rapid disappearance of free LNA and LA, with apparent half-lives of 60 and 40 min, respectively,...

A K-band CMOS broadband low noise amplifier (LNA) based on the magnetically coupled resonator (MCR) matching network technique is presented and implemented in 0.13-µm technology. Such LNA consists of two common-source (CS) pseudo-differential stages, which use capacitive neutralization to enhance inversion isolation Gain. The MCR-based input achieves good balance loss performance by inventing a...

Abstract This paper presents an analysis for a multi-stage Low Noise Amplifier (LNA) application on deep brain stimulation. A low noise amplifier with high gain, moderate bandwidth and reduced is designed simulated using LT Spice PTM BSIM4 CMOS models. The novel LNA circuit topology proposed which uses cascaded style to improve mid-band gain of LNA. achieves margin ranges between 60-67 (dB), 2X...