Pesticides are an important hazard in agriculture. They are used throughout the world and their use is strictly regulated. To assess the effects of exposure to complex mixtures of pesticides, enzyme activities are among the biomarkers that may be used to detect these effects before adverse clinical health effects occur. Exposure to pesticides for a prolonged period affects the normal functionin...

       Polyphenolics form a major part of the dietary antioxidant capacity of fruits and vegetables have been identified as chemopreventive or anticancer agents. Hydroxychalcones are polyphenols abundantly distributed throughout the plant kingdom and are compounds with two aromatic rings (benzene or phenol) and an unsaturated side chain. In the present study, effect of phloretin (apple major fl...

Recently assays of glycolytic enzymes and transaminases have significantly expanded the diagnostic possibilities of internal medicine. Thus one may confirm myocardial infarction by serum transaminase activity within the first few hours in at least 95 per cent. of all cases. The testing of these enzymes has also improved the diagnosis of virus hepatitis and other liver diseases, and their undoub...

Hepatitis C virus is associated with several immune-mediated phenomena, presented usually as extra-hepatic hepatitis C manifestations. A predisposition to autoimmunity associated with the presence of baseline autoantibodies has been demonstrated in interferon mediated autoimmune diseases. We report a male patient, 34 years old, with genotype 1, chronic hepatitis C (hepatitis C viremia 1.432.463...

BACKGROUND Trastuzumab is a humanized monoclonal antibody approved for the treatment of breast cancer with HER2 amplification and/or overexpression. There are only 2 prior cases of trastuzumab-related hepatotoxicity reported in the literature. CASE REPORT We report the case of a 60-year-old woman who was treated with trastuzumab for stage I invasive ductal carcinoma of the right breast. She s...

Intestinal ischemia-reperfusion (IIR) injury affects other organs, like the liver. Glutamine may offer liver protection, following IIR injury. Four groups of rats were studied. In Group A, the animals were subjected to 90 minutes of IIR. In Group B Alanyl-Glutamine dipeptide was administered prior to IIR. Group C, was the sham, and in Group D, the animals were given Alanyl-Glutamine dipeptide, ...

AIM To studied iron metabolism in liver, spleen, and serum after acute liver-damage, in relation to surrogate markers for liver-damage and repair. METHODS Rats received intraperitoneal injection of the hepatotoxin thioacetamide (TAA), and were sacrificed regularly between 1 and 96 h thereafter. Serum levels of transaminases and iron were measured using conventional laboratory assays. Liver ti...

ricinus communis linn. (euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. in the indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a long time. in the present study, the protective effects of ethanol extract of ricinus communis...

conclusions ehp was able to both reduce ldl-ch and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers. materials and methods thirty-two male rats weighting 200 ± 10 g were randomly divided in...

BACKGROUND Dyslipidemia secondary to highly active antiretroviral therapy in patients with HIV is associated with a significant increase in cardiovascular morbidity and mortality due to atherosclerotic disease, requiring, thus, immediate and effective treatment. OBJECTIVE To demonstrate the effectiveness and safety of rosuvastatin and ciprofibrate in the treatment of dyslipidemia associated w...