abnormal results for these tests may not bleed and blood transfusion is not entirely free from risk. Hence no transfusion is given to correct the defects unless certain positive indications are present-such as daily deterioration in test results; damage to blood vessels; and if bleeding has occurred. The amount and type of transfusion fluid to be used follows the generally accepted principles f...

liver secretes a large range of very low density lipoprotein (vldl) particles of different sizes and svedberg flotation rates (sf). in plasma vldl is converted to low density lipoprotein (ldl)which in turn plays an important role in the development of atherosclerotic diseases; however,triglyceride (tg) rich vldl1 has been shown to be more deleterious than cholesteryl ester (ce) rich vldl2. ther...

The aim of this study was to investigate the changes of the multislice computed tomography (MSCT) perfusion parameters and histopathology of the liver in rabbits with VX2 tumors before and after high-intensity focused ultrasound (HIFU) therapy. VX2 carcinoma cells were implanted into the livers of eight New Zealand white rabbits 3 weeks prior to the treatment. MSCT perfusion was performed one w...

Tumor cell resistance against melphalan (LPAM) has been associated with increased cellular reduced glutathione (GSH) levels and glutathione S-transferase activity. Therefore, GSH conjugation of LPAM has been hypothesized to be a key factor in tumor cell resistance. In the present study, we evaluated GSH conjugation of LPAM by the perfused liver in patients with colorectal cancer metastases unde...

Isolated hyperthermic antiblastic perfusion of the liver is currently gaining acceptance among surgeons and oncologists as a treatment for multiple unresectable liver metastases when conventional chemotherapy failed to halt progression of the disease [1]. Currently, new promising drugs are under investigation to further improve the efficacy of the treatment [2]. Colorectal cancer is the most se...

RATIONALE AND OBJECTIVES To develop an optimal scanning protocol for multislice spiral CT perfusion (CTP) imaging to evaluate hemodynamic changes in liver cirrhosis with diethylnitrosamine- (DEN-) induced precancerous lesions. MATERIALS AND METHODS Male Wistar rats were randomly divided into the control group (n = 80) and the precancerous liver cirrhosis group (n = 40). The control group rece...