Introduction Liver cancer is a common tumor of digestive system. Hepatectomy sometimes results in massive hemorrhage, and intraoperative autotransfusion often required. Material methods Methods: In this basic research, the liver rat model was established, visible tissue surgically removed, blood mice recovered. Results The showed that group had highest recurrence metastasis cancer, lowest group...

Hepatitis B virus (HBV) is an etiological agent of hepatitis B infection. Hepatitis B is a life-threatening disease that affects the liver. The clinical outcomes of the disease are varied from asymptomatic disease to serious complication such as cirrhosis and hepatocellular carcinoma (HCC). Despite availability of the vaccine and appropriate treatment, hepatitis B infection still remains a majo...

stromal derived factor-a (sdf-1-a) is a cxc chemokine which has been demonstrated as a recruitment factor for leukocytes to the site of inflammation, infection, injury and following stress. this chemokine has been shown to be expressed by liver cells and in liver diseases. hence, the aim of this study was to examine the expression of sdf-1 by hepatocytes in responses to the stress imposed durin...

background: it is now well established that several environmental stress factors cause activation of p38 map kinase and jnk in various cell types to produce chemokines. objective: to investigate the expression of cxc chemokines gro/kc and sdf- 1a in rat's h4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. methods: hepatoma cells were maintained in mem medium...

background: diabetes is a major public health problem. the development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. in this study, protective effects of sodium tungstate against stz-induced beta-cell damages were investigated. methods: sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...

Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring.   Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, structure functions of space a thin perisinusoidal area between endothelial cells hepatocytes filled with blood plasma, have acquired great importance in liver disease. The Disse is home for hepatic stellate (HSCs), major fibrogenic players liver. Quiescent HSCs (qHSCs) store vitamin A, upon activat...

In silico designed peptides showed high binding affinity towards activated human hepatic stellate cells, offering new strategies to target insulin-like growth factor 2 receptor in fibrotic liver and suggesting a potential for noninvasive diagnosis.

Triggering receptor expressed on myeloid cells-1 (TREM-1) is an important inflammation-related biomarker. The present study aimed to determine whether this affects the short-term prognosis of patients with acute-chronic liver failure (ACLF).