This paper reports a novel and practical microfluidic approach for culturing live tumor biopsies and multiplexing their exposure to chemotherapy drugs. Our microfluidic device offers 80 individually addressable streams which enables stimulation of multiple areas on a biopsy tissue and allows explant culture of a full core biopsy tissue while preserving the tumor microenvironment. Biopsy tissues...

We characterize long (up to 285 mm) gradient index (GRIN) lens endoscope systems for multiphoton imaging. We fabricate a portable, rigid endoscope system suitable for imaging unstained tissues, potentially deep within the body, using a GRIN lens system of 1 mm diameter and 8 cm length. The portable device is capable of imaging a ~200 µm diameter field of view at 4 frames/s. The lateral and axia...

Synopsis We describe a model-free method to quantify the spectrum of water mobilities in ៯�xed and live brain tissues. We eliminate confounds caused by anisotropic di៛�usion in brain tissues by measuring orientationally-averaged di៛�usion weighted images over a large range of b-values. Spectra of orientationally-averaged water di៛�usivities show clear distinctions between white matter, gray mat...

Fluorescent proteins (FPs) were developed for live-cell imaging and have revolutionized cell biology. However, not all plant tissues are accessible to live imaging using confocal microscopy, necessitating alternative approaches for protein localization. An example is the phloem, a tissue embedded deep within plant organs and sensitive to damage. To facilitate accurate localization of FPs within...

conclusions employing the lpe as a new approach, gives novel concept of probiotic-products in food and medical marketing. results results showed that, lpe had more antipathogenic effects, antioxidant activity, and stability during storage-time when compared to fresh probiotic-extract. objectives in this study extract of cultured probiotics without cells was evaluated for its antimicrobial effec...

hormonally active agents are widespread in the environment and exist in the human diet. there isinsufficient knowledge regarding the influence of phytochemicals on the pathophysiology of the malereproductive system. kiwi is a rich source of phytochemicals such as flavones (with estrogenic activity),serotonin and vitamin c. these components can influence the hormones and interfere with reproduct...

introduction individual x-ray diffraction patterns of biological tissues are obtained via interference of coherent scattering with their electrons. many scientists have distinguished normal and cancerous breast tissue, bone density, and urinary stone types using the x-ray diffraction patterns resulting from coherent scattering. the goal of this study was to introduce an optimized method for obt...

Fuller, in 1989, described probiotic microorganisms as “a live microbial feed supplement,which beneficially affects the host animal, by improving its intestinal microbial balance”.Saccharomyces cerevisiae var. boulardii (S.boulardii) is an accurate probiotic yeast idol.The detection and budding of S.boulardiiis firmly related to the impression of healthinessto promote microorganisms from foodst...