basic research and clinical data in an attempt to derive a cohesive model which explains the behavioral effects of the drug. Johnson is an experimental psychologist, and his work underlies many of the chapters which suggest that lithium decreases the behavioral response to novel external stimuli. He then utilizes this foundation to propose a cognitive model for lithium's anti-manic action, its ...

CASE REPORTS We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks. DISCUSSIO...

I want to emphasize, however, that at the present time only two uses of lithium are fully established: the therapeutic use in mania, and the prophylactic use in recurrent endogenous affective disorders. All other uses are based on evidence which is not yet fully conclusive even though in some instances it is quite strong. Systematic trials are required fox further substantiation. We must keep o...

Topiramate is an antiepileptic drug also used in the treatment of bipolar disorder. Several authors have reported the efficacy of topiramate in controlling the clinical manifestations of bipolar disorder and its ability to reduce the appetite, thus, the weight. Here, we present a case report showing a strong evidence of topiramate effectiveness in the treatment of obesity induced by psychotropi...

There are numerous minerals that are critical to the human body. Are there vital elements that are also necessary for the optimal functioning of the human brain? Is lithium one of these essential minerals in the central nervous system? Lithium is a natural salt. Drinking water is the most common source of nutritional lithium although it also occurs naturally in some plant-derived foods. Althoug...

Progress in the treatment of bipolar disorder Bipolar affective disorder has long been recognized as being one of the most significant causes of increased mortality and morbidity due to mental ill health. Bipolar disorder is an evolution of the older concept of manic-depressive illness, which itself was differentiated from dementia praecox/schizophrenia by Kraepelin over 100 years ago. Bipolar ...

OBJECTIVE To evaluate the evidence for the use of topiramate for alcohol dependence. DATA SOURCES MEDLINE (1966-June 2008) and Cochrane Database (2008, Issue 1) searches were conducted using the search terms alcohol dependence and topiramate. Bibliographies of selected articles were examined for additional data sources. STUDY SELECTION AND DATA EXTRACTION English-language, randomized, contr...

BACKGROUND GABAergic anticonvulsants have been recommended for the treatment of alcohol dependence and the prevention of relapse. Several studies have demonstrated topiramate's efficacy in improving drinking behaviour and maintaining abstinence. The objective of the present open-label controlled study was to assess efficacy and tolerability of low-dose topiramate as adjunctive treatment in alco...

Title of dissertation: EXPLORATION OF LITHIUM ION BINDING TO MAGNESIUM BOUND ADENOSINE TRIPHOSPHATE AND ITS IMPLICATIONS FOR BIPOLAR DISORDER Katharine Therese Briggs, Doctor of Philosophy, 2015 Dissertation directed by: John P. Marino, Ph.D. Department of Chemistry & Biochemistry Lithium carbonate, a drug for the treatment of Bipolar Disorder, provides mood stability to treat an illness that c...

Treatment of Bipolar Depression Depressive episodes are significant in bipolar illness since patients can spend up to one-third of their lives in depression. Although the treatment of bipolar depression remains an understudied area, new data from randomized, controlled trials and naturalistic studies expanded the range of treatments avaliable. The main aim in the treatment of bipolar depression...