Learning content management systems (LCMS) are web-based elearning applications that allow an instructor to deliver standards-based learning content to communities of learners. Despite the high popularity of these systems, they tend to have minimal collaborative navigation and awareness features, and students often find themselves learning in a vacuum without a sense of what the rest of the lea...

Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc., of pharmaceuticals. In this article, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including, e.g., ant...

Centrifugated extract of endophytic Pseudomonas azotoformans strain UICC B-91 has been observed for its antimicrobial activity against Escherichia coli ATCC 8739, Bacillus cereus 10876, Staphylococcus aureus 6583, 25923, Salmonella typhimurium 25241, aeruginosa 15442, subtilis 19659 and Candida albicans 10231, with minimum concentration in the range 250 μg/mL. But, novel compound bioactive subs...

Fried and baked banana-based snacks are popular in South East Asia and banana chip is popular in other countries, such as India, Indonesia, China, African countries, etc; these snacks may contain acrylamide in concentration which may be of concern due to its toxicity. This study was carried out to determine acrylamide concentration in popular banana based snacks in Malaysia using a modified met...

Isotope dilution mass spectrometry with liquid chromatography for the determination of serum creatinine is studied. After adding labeled (15N2) creatinine to the serum, creatinine was isolated using high performance liquid chromatography. Measurements were performed by electron impact mass spectrometry with use of a direct insertion device. Analytical results of the NIST (formerly NBS) SRM seru...

The aim of this study was to investigate the effect of testosterone and oestrogen on regulating organic cation transporters (Octs) and multidrug and toxin extrusions (Mates) expression in the kidney of mice and urinary excretion of metformin. 8 week-old male db/db mice were treated with estradiol (5 mg/kg), testosterone (50 mg/kg) or olive oil with same volume. Metformin (150 mg/kg) was injecte...

Citation: Zhang X, Li J, Xie B, Wu B, Lei S, Yao Y, He M, Ouyang H, Feng Y, Xu W and Yang S (2018) Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry. Front. Pharmacol. 9:282. doi: 10.3389/fphar.2018.00282 Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Muci...

Celery (Apium graveolens L.) is a plant that belongs to the Apiaceae family and widely used as medical for low blood pressure, heart tonic, prevent cardiovascular disease. This study aims obtain flavonoid compounds, identify, test antioxidant activity of compounds crude extracts from celery leaves. The research procedures consisted four steps, first which was preliminary test. second step invol...

Objective: Alzheimer’s disease (AD) is a neural degenerative disease with progressive cognitive impairment. N-acetyl aspartic acid (NAA) is an important biomarker for assessing neuronal activity and brain cells metabolic abnormalities. This investigation is aimed to establish a liquid chromatography-mass spectrometry (LC-MS) method for measuring plasma NAA level, in order to make clear whether ...

Indole-3-acetic acid (IAA) is the most important member of the group of phytohormones known as auxins, which regulate many aspects of plant growth and development. The concentration of IAA in cells and tissues is controlled by various mechanisms, including de novo biosynthesis, synthesis and hydrolysis of IAA conjugates, conversion of IAA to indole-3-butyric acid (IBA), and oxidative degradatio...