BACKGROUND AND PURPOSE Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity, which is the rate-limiting enzyme in the synthesis of prostaglandins. Previous studies have indicated that NSAID therapy, and in particular NSAIDs that specifically target the inflammatory cyclooxygenase (COX-2), impair bone healing. We compared the effects of ibuprofen and rofecoxib on ...

In this study, the energy consumption in the food and beverage industries of Iran was investigated. The energy consumption in this sector was modeled using artificial neural network (ANN), response surface methodology (RSM) and genetic algorithm (GA). First, the input data to the model were calculated according to the statistical source, balance-sheets and the method proposed in this paper. It ...

Indomethacin and ibuprofen are administered to close a patent ductus arteriosus (PDA) during active glomerulogenesis. Light and electron microscopic glomerular changes with no change in glomerular number were seen following indomethacin and ibuprofen treatment during glomerulogenesis at 14 days after birth in a neonatal rat model. This present study aimed to determine whether longstanding renal...

flammation drugs (NSAIDs) and it is clinically the first choice among its own class, 2-arylpropionic acids, due to its low incidence of unwanted effects. It contains a chiral center adjacent to the carboxyl group and thus existed as ( ) R and ( ) S enantiomers. Ibuprofen was originally marketed as racemate and later in 1994 dexibuprofen was brought into the market in Austria and Switzerland bas...

Ibuprofen is a well established analgesic, anti-inflammatory and antipyretic NSAID. In three double-blind, multicentre trials in postoperative adult patients (n = 185-406), intravenous ibuprofen 800 mg once every 6 hours, as an adjunct to morphine, significantly reduced the consumption of morphine compared with placebo, as an adjunct to morphine, in two of the three trials (primary endpoint in ...

BACKGROUND Patent ductus arteriosus (PDA) is a common cause of morbidity. The aim of this study was to compare the efficacy of oral Acetaminophen and oral Ibuprofen for the closure of patent ductus arteriosus (PDA) in preterm infants. OBJECTIVES This study demonstrated that, there was no significant difference between treatment of PDA with either oral Acetaminophen or oral Ibuprofen in preter...

BACKGROUND Severe pulmonary hypertension may following ibuprofen administration for ductal closure. CASE CHARACTERISTICS An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration. OUTCOME Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications relat...

The esterification of rac-ibuprofen and rac-ketoprofen with glycerol catalyzed the commercial biocatalyst Novozym® 435 was investigated at 45 °C various profen: molar ratios using 2-propanol as co-solvent in a batch type reaction. conversion reached 46%, an enantiomeric excess towards S-enantiomer 42%. When 1:4 ibuprofen:glycerol ratio assayed, 75% R-ibuprofen reacted monoglyceride 99% selectiv...