Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as bot...

pH-responsive liposomes were prepared by modifying the liposome with acid-cleaving amphiphiles. Palmitic ketohydrazone (P-KH) or stearic ketohydrazone (S-KH), composed of hydrophilic sugar headgroup and hydrophobic acyl chain, was used as a modifier of the DMPC liposome. Because the ketohydrazone group of P-KH or S-KH was cleaved at low pH conditions (<pH 5.0), the delivery of the P-KH modified...

The objective of this study was to investigate the influence of surfactant charge, surfactant carbon chain length, and surfactant content on the physicochemical characteristics (ie, vesicle size, zeta potential, elasticity, and entrapment efficiency), morphology, stability, and in vitro skin permeability of meloxicam (MX)-loaded liposome. Moreover, the mechanism for the liposome-enhanced skin p...

Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clinical strains of P. aeruginosa and to define the mechanism of liposome-bacteriu...

OBJECTIVE(S) Soluble Leishmania antigens (SLA) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. Liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-A (PLA) activity of SLA is a drawback to prepare a stable liposomal SLA. One strategy to overcome this problem might b...

Methotrexate (MTX) is the single most effective agent for the treatment of primary central nervous system lymphoma. Currently, the delivery of MTX to the brain is achieved by high systemic doses, which cause severe long-term neurotoxicity, or intrathecal administration, which is highly invasive and may lead to infections or hemorrhagic complications. Acoustically active microbubbles have been d...

The hadronic events collected by LEP between 1989 and 2000 have changed dramatically our understanding of QCD, which has now been established as a part of the Standard Model. Still in many sectors (nonperturbative in particular) science analysis needs to be completed, and some new studies are just starting: LEP physics is still the best hadronic physics at accelerators, at least in Europe.

Reconnections among the produced colour dipoles in the Dipole Cascade Model are discussed, and an implementation in the Ariadne program is presented. The reconnections are shown to have only small effects on event shapes at LEP 1, on the W mass determination at LEP 2 and on rapidity gaps in deep inelastic scattering at HERA. Submitted to Z. Phys. C CERN–TH/95–218 August 1995

A review of the results on B 0-B 0 mixing and b-lifetimes obtained by CDF, LEP and SLD collaborations is presented with special emphasis on B 0 s-B 0 s mixing.

A review of some of the latest results on heavy flavor physics from the LEP Collaborations is presented. The emphasis is on B physics, particularly new results and those where discrepancies with theory are emerging. A brief description is given of the many techniques which have been developed to permit these analyses.