A facile approach for the preparation of crosslinked polymeric nanocapsules was developed by the combination of the surface-initiated atom transfer radical polymerization and ultraviolet irradiation crosslinking techniques. The well-defined polystyrene grafted silica nanoparticles were prepared via the SI-ATRP of styrene from functionalized silica nanoparticles. Then the grafted polystyrene cha...

Unbalanced western-style diet and a sedentary lifestyle are increasingly recognized as important contributors to the observed increase in obesity and chronic diseases in the western world. Supplementing foods with health promoting bioactive ingredients poses a major technological challenge since some of these constituents, like omega-3 poly-unsaturated fatty acids (PUFA), exhibit poor chemical ...

Attaching polysaccharides to the surface of nanoparticles offers the possibility of modifying the physicochemical and biological properties of the core particles. The surface of lipid nanocapsules (LNCs) was modified by post-insertion of amphiphilic lipochitosan (LC) or lipodextran (LD). Modelling of these LNCs by the drop tensiometer technique revealed that the positively charged LC made the L...

There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include ω-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their...

Lipid nanocapsules (LNCs) have proven their efficacy in delivering different drugs to various cancers, but no studies yet described uptake mechanisms, paclitaxel (PTX) delivery or resulting cytotoxicity towards breast cancer cells. Herein, we report results concerning cellular of LNCs and PTX-loaded (LNCs-PTX) on the three cell lines MCF-7, MDA-MB-231 MDA-MB-468. LNCs-PTX sizes 50 ± 2 nm, 90 3 ...