The MsbA protein is an essential ABC (ATP-binding-cassette) superfamily member in Gram-negative bacteria. This 65 kDa membrane protein is thought to function as a homodimeric ATP-dependent lipid translocase or flippase that transports lipid A from the inner to the outer leaflet of the cytoplasmic membrane. We have previously shown that purified MsbA from Escherichia coli displays high ATPase ac...

abstract: in a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely urazoles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. the structures of these compounds have been investigated by spectral data. the synthesized compounds...

In this study, we present a series of solvatochromic phenylbenzothiadiazoles that display dual emission from the locally excited (LE) and intramolecular charge transfer (ICT) states. The donor-acceptor derivatives are highly sensitive to polarity changes, which can be monitored by differences in efficiency, spectroscopic shifts variations LE/ICT ratio. One compounds series, containing thiomethy...

Atherosclerosis is an independent risk factor for cardiovascular diseases, which related to dyslipidemia, endothelial injury, inflammation, thrombosis, dysfunction of vascular smooth muscle cells and macrophages, etc. Puerarin, a natural monomer from Chinese herb Pueraria lobata, presents multiple protective activities. The paper firstly reviewed the factors drug atherosclerosis. And then, extr...

The methanogenic archaebacterium Methanospirillum hungatei contains two unusual phosphoglycolipids that account for 64 percent of the total cellular lipids. These lipids are derivatives of the dibiphytanyl diglycerol tetraether, previously identified in methanogens. One of the free hydroxyls of this tetraether is esterified with glycerophosphoric acid, and the other is linked glycosidically to ...

A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides--analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their ability to interact with lipid bilayers. The influence of the new derivatives of piroxicam on liposome...

We performed the biochemical analysis and studied chemical composition of blood samples in 163 people 45-90 years old with type 2 diabetes mellitus dyslipidemia. examined concentrations following compounds samples: fatty acids, aldehydes, styrenes microbial origin, as well levels glucose, triglycerides, cholesterol, lipids low high density. The was determined by gas chromatography-mass spectrom...

l. S-alkyl glycerol ethers were isolated by thin-layer chromatography from the total lipids of Ehrlich ascites cells following reduction with vitride. 2. Gas-liquid chromatography of the isopropylidene derivatives showed the principal component to be 16:O (83*,i) with lesser amounts of 1X:1 (14%) and 18:O (2”:;). 3. Quanti~dtive analysis yielded values of about 2~moles~~~mg lipid for the isolat...

Treatment of coenzyme Q with ozone, permanganate, and ferrous sulfate in presence of ascorbate or hydrogen peroxide yielded water-soluble degradation products, possibly having truncated side-chain and modified ring.These derivatives, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. Representative samples of these also decreased blood pressure w...