This article presents a model for regulating cognitive enhancement devices (CEDs). Recently, it has become very easy for individuals to purchase devices which directly modulate brain function. For example, transcranial direct current stimulators are increasingly being produced and marketed online as devices for cognitive enhancement. Despite posing risks in a similar way to medical devices, dev...

Hyperthermic enhancement of cis-diammine-l,l-cyclobutane dicarboxylate platinum(II) (carboplatin) cytotoxicity was studied in vitro in .IM, a human acute lyntphoblastic leukemia cell line. Corrected for direct heat toxicity, hyperthermia enhanced carboplatin killing at the clinically relevant temperatures of 40.5°and 41.8°C.The thermal enhancement ratios at these temperatures were 1.89 and 33...

In this contribution we optimize a speech enhancement preprocessor such that a distortion measure in the Line Spectral Frequency (LSF) domain is minimized. We can thus improve the estimation of spectral parameters of a speech coder when the input signal to the coder is a noisy speech signal. The optimization aims at the maximum noise reduction of the enhancement preprocessor. The average maximu...

Genome editing allows for the versatile genetic modification of somatic cells, germ cells and embryos. In particular, CRISPR/Cas9 is worldwide used in biomedical research. Although the first report on Cas9-mediated gene modification in human embryos focused on the prevention of a genetic disease in offspring, it raised profound ethical and social concerns over the safety of subsequent generatio...

BACKGROUND AND PURPOSE Gamma knife radiosurgery is an alternative for the treatment of medically refractory trigeminal neuralgia. Few reports of posttreatment MR imaging appearance of cranial nerve V exist. Our purpose was to define MR imaging characteristics in cranial nerve V after gamma knife radiosurgery. METHODS We retrospectively reviewed MR images of 15 patients who underwent gamma kni...

the present work is an experimental study of steady state convective heat transfer of de-ionized water with a (0.04% by volume) volume fraction of al2o3 nanoparticles dispersed to form a nanofluid that flows through an aluminium tube.laminar fully developed flow heat transfer coefficient of al2o3 nanoparticles are dispersed in water in circular tube is discussed in this paper. in order to valid...