The intestinal tract is a complex ecosystem that combines resident microbiota and the cells of various phenotypes with complex metabolic activities that line the epithelial wall. The intestinal cells that make up the epithelium provide physical and chemical barriers that protect the host against the unwanted intrusion of microorganisms that hijack the cellular molecules and signaling pathways o...

Abstract The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial damage, exposure various barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic autoimmune diseases. Particularly, introduction more than 200,000 new chemicals our daily lives since 1960s has played a major role in pandemic increase these const...

Double-barrier GaAs/AlAs resonant tunneling diodes (RTDs) have become the promising elements for development of sub-mm and THz emitters. We report on fabrication RTD samples that were characterized via RF-reflectometry to determine parameters its equivalent circuit. By using numerical simulation we show coplanar transmission line with under study provides an amplification up 8 GHz.

Software product line engineering is an efficient means to generate a set of tailored software products from a common implementation. However, adopting a product-line approach poses a major challenge and significant risks, since typically legacy code must be migrated toward a product line. Our aim is to lower the adoption barrier by providing semiautomatic tool support—called variability mining...

Past studies have demonstrated that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors can significantly improve clinical outcomes in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) and sensitive EGFR gene mutations. Gefitinib (Iressa(®)), the first oral EGFR tyrosine kinase inhibitor, has been shown to be more effective and better tolerated than ...

in this paper two different methods are presented to approximate the solution of the fractional black-scholes equation for valuation of barrier option. also, the two schemes need less computational work in comparison with the traditional methods. in this work, we propose a new generalization of the two-dimensional differential transform method and decomposition method that will extend the appli...

according to statistics released by agricultural insurance fund (aif) less than 4 million acres out of 90 million acres has been covered by pastures insurance. this observation along with several facts motivated authors to study possible barriers which pastures insurance has been encountered in practice. the research population included all the experts in agricultural insurance fund. small popu...

results long-term exposure to lead acetate caused histopathology effects including dilatation, congestion, nuclei heterochromatic effects, increase in diameter of renal tubules and urinary barrier thickness in rabbit renal tissue. conclusions quantitative and qualitative results of long-term lead acetate exposure showed many histopathology side-effects, especially in the urinary barrier. materi...