Lesions on the ocular surface can destroy the stem cells from the limbus and cause limbal stem cell deficiency. The limbal stem cell deficiency is marked by conjunctivalization, which can be defined as the invasion of conjunctival epithelium over the cornea. This process is accompanied by varying degrees of corneal changes such as neovascularization, inflammation, recurrent erosions, persistent...

Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central cornea. Diabetes mellitus (DM) affects all the structures of the eye including the cornea. Frequent epithelial erosions, delayed wound healing, ...

Compared with the peripheral corneal limbus, the human central cornea lacks blood vessels, which is responsible for its immunologically privileged status and high transparency. Dendritic cells (DCs) are present in the central avascular area of inflamed corneas, but the mechanisms of their migration to this location are poorly understood. Here, we investigated the contribution of vessel formatio...

A 20-year old male patient sustained trauma to the right eye by stone 7 years prior to presentation. The patient's right eye had corneal scar, sectoral traumatic cataract and chronic retinal detachment in which retinal detachment repair was done. Seven years later, the patient presented with intracorneal epithelial ingrowth, which was confirmed by histopathology. Conjuctival peritomy was done s...

310 CMYK Figure 2: (a) Calcofluor white stain of the corneal scraping showing septate, branched fungi with chlamydospores. (x250). (b) Eight day old growth of the fungus on potato dextrose agar showing Grey, fluffy colonies with black granules on the surface. (c) Lactophenol cotton blue wet mount of the colony showing falcate conidia (shown with arrowheads), and conidiomata, upon which darkly p...

The regenerated epithelium derived from limbal epithelium was histologically and biochemically compared with epithelia regenerated from corneal and bulbar conjunctival epithelia. The histologic results indicated that regenerated epithelium of limbal origin increased in thickness with time after healing and showed no goblet cell appearance on the cornea. This suggests that regenerated epithelium...

MANY theories are put forward and discussed in the literature regarding the nature of pterygium, and many papers were written on the subject, fewof which tried in a precise way to describe exactly how the pterygium is formed. The aim of this paper is to report the results of a six years' investigation of the subject iii a locality full of cases of pterygia. It discusses a new theory of its deve...

Congenital intrascleral cysts are rare. They are mostly located at the limbus with corneal involvement. We report a case of a 30-month-old boy with a bulber conjunctival cyst noticed at birth. The lesion enlarged over the following months but did not involve the cornea. During surgery the cyst proved to be intrascleral and a complete excision was carried out. The remaining defect was repaired w...