Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency. While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little has been reported regarding the potential health risks associated with production processes and transplantation techniques. Culture procedures...

This paper reviews the data in the published literature (PubMed from 1937 to 2011) concerning the medical and surgical management of pediatric limbal dermoids. Current standard medical treatment for grade I pediatric limbal dermoids (ie, with superficial corneal involvment) is initially conservative. In stages II (ie, affecting the full thickness of the cornea with/without endothelial involveme...

To present reversal of sensation of conjunctival limbal autograft. A 48-year-old female presented with red-colored mass in the left eye involving the temporal bulbar conjunctiva and limbus. It was vascular, elevated, compressible and immobile. Excisional biopsy, and conjunctiva limbal autgrafting with fibrin glue was performed, and histopathologic examination confirmed the diagnosis of capillar...

CLINICAL REPORT We report a case of a 29-year-old lady, with known Chronic Granulomatous Disease, who presented with an acneiform scarring facial and trunk eruption and sore red eyes. Slitlamp examination showed limbal granulomas and adjacent peripheral ulcerative keratitis. DISCUSSION The authors are considering the possible causes of the keratitis. As there were no signs of blepharitis at t...

Regenerative medicine for the cornea provides a novel treatment strategy for patients with corneal diseases instead of conventional keratoplasty. Limbal transplantation has been performed in patients with a limbal stem cell deficiency. This procedure requires long-term immunosuppression that involves high risks of serious eye and systemic complications, including infection, glaucoma, and liver ...

Nager syndrome, also called preaxial acrofacial dysostosis, comprises two groups of defects involving the limbs and craniofacial region, respectively. This syndrome is rare and only 70 cases have been reported in the literature. The exact cause of this syndrome is unknown, but there is indication that it is genetically based. Ocular manifestations of this syndrome include widely separated downw...

Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data...

This paper describes an improvement in the technique of limbal incision of the conjunctiva in squint operations. The limbal incision was first described by Zugsmith (I959) as a peritomy incision, but Massin and Hudelo (I962) were the first to show its full advantage in squint surgery, and von Noorden (i 968, i 969) improved the technique. The limbal incision has the merits of providing a scarle...