In ether-à-go-go (eag) K(+) channels, extracellular divalent cations bind to the resting voltage sensor and thereby slow activation. Two eag-specific acidic residues in S2 and S3b coordinate the bound ion. Residues located at analogous positions are approximately 4 A apart in the x-ray structure of a Kv1.2/Kv2.1 chimera crystallized in the absence of a membrane potential. It is unknown whether ...

background:   primary bone lymphoma or non-hodgkin lymphoma of bone is a rare disease. there are only a few case series of stage ie of this condition in medical literature. the aim of this study is to determine the rate of survival   for stage ie after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     methods:   we col...

background: massive bone allograft is an option in cases of limb preservation and reconstruction after massive benign and malignant bone tumor resection. the purpose of this study was to analyze the outcome of these procedures at imam reza hospital, mashhad university of medical sciences. methods: in this study, 113 cases have been presented. eleven cases were excluded (patients has a traumatic...

normal axial alignment restoration in lower extremities is crucial for surgeons performing reconstructive surgeries. since reference normal values of axial alignment are affected by age, sex, and ethical issues, we tried to scrutinize these parameters in iranian adults and compare them with normal values in literatures. through a cross-sectional design, standing axial alignment views of lower e...

This study investigates blood pressure (BP) and heart rate (HR) short-term variability and spontaneous baroreflex functioning in adult borderline hypertensive rats and normotensive control animals kept on normal-salt diet. Arterial pulse pressure was recorded by radio telemetry. Systolic BP, diastolic BP and HR variabilities and baroreflex were assessed by spectral analysis and the sequence met...

An intermolecular Zn(2+)-binding site was identified in the structure of the T1 domain of the Shaw-type potassium channels (aKv3.1). T1 is a BTB/POZ-type domain responsible for the ordered assembly of voltage-gated potassium channels and interactions with other macromolecules. In this structure, a Zn(2+) ion was found to be coordinated between each of the four assembly interfaces of the T1 tetr...