Methamphetamine (MA), a highly addictive psychostimulant, produces long-lasting neurotoxic effects well proven in nigrostriatal dopaminergic neurons. Considering the similarities between pathological profile of MA neurotoxicity and Parkinson's disease (PD), some reports show that previous MA abusers will be at greater risk of PD-like motor deficits. To answer the question if repeated MA exposur...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

background: testosterone level in men decreases with aging (andropause) and androgen deficiency is responsible for a variety of behavioral symptoms such as anxiety. the aim of this study was to investigate the effect of pistacia atlantica (bane) fruit extract on anxiety-like behavior in intact and gonadectomized rats. materials and methods: in this study, adult male rats were divided into two g...

Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in p...

Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

Stress may cause special behavioral and biochemical changes. Kindling is presumed to be the underlying mechanism for such changes. Lamotrigin, an anti-kindling agent which blocks glutamate release through inhibiting sodium channels may reverse these behavioral changes. The aim of this study was to explore the effects of lamotrigin in management of behavioral and biochemical changes caused by st...

a semi-micromechanical multilaminate model is introduced here to predict the mechanical behavior of soils. this model is like a bridge between micro and macro scale upon the satisfaction of minimum potential energy level during any applied stress/strain increments. the concept of this model is based on a certain number of sampling planes which constitute the elastic-plastic behavior of the soil...

organizational citizenship behavior (ocb) is based on the thought that contain the variety of the staff behavior like moral duties, voluntary assistance, doing duties without formal monitoring and endure adversity. enhancement of the ocb can be facilitated the movement of the traditional organizations into the new competitive environment and increased organizational effectiveness. the purpose o...

rational emotive behavior therapy (rebt) is based on the concept that emotions and behaviors are results of cognitive processes. there is a possibility for the human being to gain better ways for feeling and behavior in case of amending many processes. rebt is one of cognitive-behavioral therapies which is very much like cognitive therapy developed by aaron t. beck in 1960 although it’s separat...