AIM High on-clopidogrel platelet reactivity (HCPR) and high on-aspirin platelet reactivity (HAPR) are associated with atherothrombotic events following coronary stenting. There are, however, few data concerning high on-treatment platelet reactivity to both aspirin and clopidogrel simultaneously. The aim of the present study was to determine the incidence of dual high on-treatment platelet react...

Clopidogrel is a prodrug that has to be converted in vivo to its active metabolite by cytochrome (CYP)P450 iso-enzymes. As calcium channel blockers (CCBs) are inhibitors of CYP3A4, concomitant use of these drugs might play a role in the wide inter-individual variability in the response to clopidogrel. However, some CCBs also have strong inhibitory effects on the drug transporter P-glycoprotein ...

BACKGROUND No data exist about the impact of high residual platelet reactivity (HRPR) after clopidogrel loading on long-term clinical outcome in patients undergoing drug-eluting stent (DES) implantation for unprotected left main disease (ULMD). METHODS AND RESULTS Consecutive patients who underwent percutaneous coronary intervention for ULMD had prospective platelet reactivity assessment by l...

BACKGROUND The TRITON-TIMI 38 study has identified three subgroups of patients with a higher risk of bleeding during treatment with the thienopyridine prasugrel: patients with a history of stroke or transient ischaemic attack (TIA), patients ≥75 years and patients with a body weight <60 kg. However, the underlying pathobiology leading to this increased bleeding risk remains to be elucidated. Th...

BACKGROUND Antiplatelet properties of omega-3 polyunsaturated fatty acids (PUFA) have been demonstrated in patients with coronary artery disease (CAD). It is unknown whether omega-3 PUFA can enhance platelet inhibition on standard aspirin and clopidogrel treatment in the setting of CYP2C19 loss-of-function polymorphism. AIM To investigate whether omega-3 PUFA are able to modify platelet respo...

  Objective: Zirconia cores have limited light transmittance and data are scarce on light transmission through zirconia cores with and without the veneering ceramic.   Methods: In this in vitro study, Disc-shaped specimens (11.5 mm in diameter and 0.4 (0.05) mm in thickness) were fabricated of three types of zirconia namely Mamut, Heany and ZirkonZahn (n=5). A disc-shaped specimen (11.5 mm in d...

Thrombopathies; Impedance aggregometry; PRP aggregometry Abstract Brahimi et al. in this journal formed a hypothesis that ‘‘the platelet count is underestimated, by an automated cell counter, each time platelet aggregates are present in the sample tube.’’ The addition of a platelet agonist to a stimulated sample tube will lead to the formation of platelet aggregates and hence to a drop in the p...