[Editorial Note: The Pioneer Health Centre at Peckham (often called the Peckham Health Centre) has recently attracted a good deal of historical attention, including an article in this journal by Jane Lewis and Barbara Brookes (Med. Hist., 1983,27: 151-161). The author of the present article, Dr Kenneth Barlow, has long been associated with the Pioneer Health Centre Ltd, presently serving as its...

The Yamamoto aldol reaction is a vinylogous aldol reaction that relies on bulky aluminium-based Lewis acids. These activate both the aldehyde as well as become part of the enolate moiety. The report discloses the first detailed study on the substrate-controlled Yamamoto aldol reaction in which 2,3-syn and 2,3-anti disubstituted aldehydes serve as the stereodirecting elements. The "size" of the ...

Endothelial carbohydrate binding proteins, Eand P-selectins, are thought to mediate sialyl Lewis A/X-dependent hematogenous cancer metastasis. We tested this hypothesis using sialyl Lewis X-dependent B16 melanoma lung targeting and its inhibition with selectin ligand mimicry peptide, IELLQAR. In E/P-selectin doubly deficient mutant mice, sialyl Lewis X-expressing B16 melanoma cells colonized th...