BACKGROUND Immune monitoring by flow cytometry is a fast and highly informative way of studying the effects of novel therapeutics aimed at reducing transplant rejection or treating autoimmune diseases. The ONE Study consortium has recently initiated a series of clinical trials aimed at using different cell therapies to promote tolerance to renal allografts. To compare the effectiveness of diffe...

BACKGROUND/AIMS Calprotectin, a 36 kDa protein present in neutrophil cytoplasm, has antimicrobial and apoptosis inducing activities, which are reversed by the addition of zinc. Matrix metalloproteinases (MMPs), a family of zinc dependent enzymes, are important in many normal biological processes including embryonic development, angiogenesis, and wound healing, but also pathological processes su...

Aldosterone seems to play a role in the regulation of the electrolyte content of sperm and in the motility of spermatozoa. The aim of the study was to evaluate the presence of the mineralocorticoid receptor (MR) in human ejaculated spermatozoa. We have assayed MR on spermatozoa of freshly ejaculated sperm from healthy donors. The identification of MR was made by using immunohistochemistry and i...

markedly elevated111 in labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mtc mdp bone scintigraphy. this finding was later confirmed by surgical pathology. the patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. the fohow-up three pha...

Suitable physiological condition in fishes for the selection of broodfishes can be achieved through hematological studies. The present study aimed to examin the hematological indices in Juvenile Sturgeons at different stages of growth. Total albumin content in blood serum, hemoglobin concentration, the erythrocyte and leukocyte count of 54 sturgeon specimens (Persian sturgeon Acipenser persicus...

BACKGROUND In Duchenne muscular dystrophy (DMD), previous freeze-fracture electron microscopic studies demonstrated that muscle plasma membrane contained markedly decreased numbers of orthogonal arrays. Recent investigations showed that orthogonal arrays were composed of aquaporin 4 (AQP4) molecules, a member of the water channel protein family. OBJECTIVES To study whether the immunostainabil...

Background: According to World Health Organization guideline (WHO 2010), seminal leukocyte concentration over 1×106/mL is a threat for sperm quality because of their role in reactive oxygen species (ROS) production, lipid per-oxidation (LPO) and later DNA fragmentation (DF). However, this threshold is equal for all semen samples without attention to their qualities. Therefore this study was set...

There is clinical interest in the modulation of regulatory T cells for cancer therapy. The safety of these therapies in combination with conventional anti-cancer therapies, including radiation therapy, can be studied in animal models. The effects of partial depletion of regulatory T (Treg) cells with an anti-CD25 antibody in conjunction with ionizing radiation on inflammation and tissue injury ...