OBJECTIVES Although previous studies have investigated the effect of human leukocyte antigen matching on long-term outcomes after heart transplants, its role in the prognosis after a heart transplant remains unclear, particularly with respect to short-term survival. MATERIALS AND METHODS We evaluated the human leukocyte antigen mismatch on in-hospital mortality of 158 consecutive patients who...

BACKGROUND It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like fashion, including capturing, rolling, adhesion, and transmigration. However, the molecular mechanisms of inc...

Leukocyte infiltration in atherosclerosis has been extensively investigated by using histological techniques on fixed tissues. In this study, intravital microscopic observations of leukocyte recruitment in the aorta of atherosclerotic mice were performed. Interactions between leukocytes and atherosclerotic endothelium were highly transient, thereby limiting the ability for rolling leukocytes to...

PURPOSE This study was designed to investigate the suppressive effects of antithrombin (AT)III on inflammatory reactions during endotoxin-induced uveitis (EIU) in rats by studying leukocyte-endothelium interactions. METHODS EIU was induced in Lewis rats by footpad injection of lipopolysaccharide (LPS). ATIII was administered immediately after or at 6 hours after LPS injection. Its suppressive...

In this research, acute toxicity (LC) of zinc oxide nanoparticle on Beluga (Huso huso) andcommon carp (Cyprinus carpio) was studied. The experiment was conducted using theOrganization for Economic Co-operation and Development (No. 202) method. For bothspecies, 96hLC10 was determined to be more than 200 mg/l. To assess the effects of zinc oxidenanoparticles on blood factors, leukocyte index coun...

Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated inflammatory diseases including COPD, but their association COPD severity remains unknown. We analyzed different MV populations plasma and bronchoalveolar lavage fluid (BALF) taken from 62 patie...