background: hairy cell leukemia (hcl) is a chronic b-cell lymphoid leukemia characterized by pancytopenia, splenomegaly, myelofibrosis and the presence in peripheral blood, bone marrow and spleen of atypical lymphoid cells with a hairy aspect. the study aims to evaluate a group of patients with hairy cell leukemia, hospitalized in the clinic of hematology and oncology, kermanshah, iran, on a pe...

Gangliosides from normal leukocytes and the cells of 25 patients with acute and chronic leukemia were tested for the presence of the disialoganglioside H3-a-A/-acetylneuraminosyl«2->8-W-aœtylneuraminosyllactosylceramide (GM). GDawas de tected by immunostaining thin-layer chromatographs with an anti-Gos monoclonal antibody (AbR24). Among the myetoid cells tested, acute leukemia cells were posi...

The response of human myeloid leukemia cells to various sources of colony-stimulating activity (CSA) and media conditioned by phytohemagglutinin-stimulated mononuclear cells (PHA-LCM) was investigated in liquid and colony culture. PHA-LCM, placenta-conditioned medium, GCT cell line-conditioned medium, leukocyte-conditioned medium, and partially purified CSA for human and murine cells were teste...

Hemophagocytic lymphohistiocytosis (HLH) is a high-fatality disease caused by hereditary or acquired immune dysfunction, and characterized pathological inflammatory response. Primary HLH (pHLH) has genetic defects, secondary (sHLH) variety of underlying diseases. Here, we report the case patient with aggressive natural killer cell leukemia HLH-related gene defects who achieved long-term surviva...

Simian antisera to human leukemia cells were able to distinguish antigens specific for lymphocytic types of leukemia from those expressed on certain myeloid leukemia cells. In this investigation, cells from acute myelomonocytic leukemia patients (AMML) were examined for their membrane-associated leukemia antigens. Simian antisera to both lymphocytic and myelogenous leukemia cells lysed cells fr...

Tumor suppressor genes are highly affected during the development of leukemia, including circadian clock genes. Circadian rhythms constitute an evolutionary molecular machinery involving many genes, such as BMAL1, CLOCK, CRY1, CRY2, PER1, PER2, REV-ERBa, and RORA, for tracking time optimizing daily life day-night cycles seasonal changes. For circulating blood cells these coordinate their prolif...

introduction: the telomeric dna together with its associated  proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with  development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...

Abstract Spinacia oleracea L., Amaranthaceae, leaves cultivated in Egypt demonstrated a potential antileukemic activity against the chronic myeloid leukemia, K562 cell line. Thus, aim of this study is to carry out phytochemical investigation S. as well isolation its phytoconstituents. Phytochemical resulted seventeen known compounds. The biological revealed that compounds hexaprenol, phytol, an...

Background: B-cell chronic lymphocytic leukemia is the most frequent leukemia in the western world while T-cell large granular lymphocytic leukemia with cytotoxic (CD8+/CD3+CD4-) immunophenotype is rare. There is much ongoing interest regarding the interaction between T cells and B-cell chronic lymphocytic leukemia cells. Methods: Peripheral blood and bone marrow samples from a 72 year-old-man ...