Oxytocin (Oxt), a neuropeptide produced in the hypothalamus, is implicated in regulation of feeding. Recent studies have shown that peripheral administration of Oxt suppresses feeding and, when infused subchronically, ameliorates hyperphagic obesity. However, the route through which peripheral Oxt informs the brain is obscure. This study aimed to explore whether vagal afferents mediate the sens...

Brown, Julie A., Streamson C. Chua, Jr., Shun Mei Liu, Matthew T. Andrews, and John G. Vandenbergh. Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R320–R330, 2000.—Five allelic mutants of the diabetes (db) gene have been previously described in mice and rats causing obesity, infertility, and va...

A role for the kinin B1 receptor in energy-homeostatic processes was implicated in previous studies; notably, the studies where kinin B1 receptor knockout mice (B1-/-) were shown to have impaired adiposity, impaired leptin and insulin production, lower feed efficiency, protection from liver steatosis and diet-induced obesity when fed a high fat diet (HFD). In particular, in a model where the B1...

BACKGROUND/AIMS Calcium and dairy proteins have been postulated to explain why the intake of dairy products correlates inversely with body mass index in several populations. We have shown that a high-calcium diet with whey protein attenuates weight gain and now we describe the effects of this diet on adipose tissue gene expression. METHODS Nine-week-old C57Bl/6J mice were divided into two gro...

Continuous subcutaneous administration of leptin normalizes blood glucose levels in rodent models of Type 1 and Type 2 diabetes independent of changes in food intake, body weight, and plasma insulin. We tested whether an acute intravenous leptin infusion changed blood glucose in normal and diet-induced leptin-resistant rats to determine whether this measure could be used as a marker of leptin s...

Free and receptor-bound leptin may be regulated by different mechanisms. Genes that influence the concentration of these fractions may have an important functional bearing. We determined circulating leptin receptor concentrations, bound as well as free leptin concentrations, and body composition in 24 monozygotic (MZ) and in 22 dizygotic (DZ) twin pairs. Bound leptin and leptin receptor concent...

Peripheral and hypothalamic mechanisms underlying the hyperphagia of lactation have been investigated in sheep. Sheep were fed ad libitum and killed at 6 and 18 days of lactation; ad libitum-fed nonlactating sheep were killed as controls. Despite increased food intake, lactating ewes were in negative energy balance. Lactation decreased plasma leptin and adipose tissue leptin mRNA concentrations...

background: to investigate the relation between serum leptin levels and cerebral infarction (ci) by meta-analysis. materials and methods: scientific literature databases were searched for studies published in chinese and english. after retrieving relevant articles through database searches and screening using predefined selection criteria, high-quality studies related to our research topic were...

background and aims: leptin is a hormone known to control appetite and body weight. the leptin levels in obese animals are always more than animals with normal size. a wide variety of methods have been offered to treat obesity of which herbal therapy is considered as one of these methods. the aim of this study was to investigate the effect of ethanolic extract of asian red ginseng on leptin ser...