Leprosy is a treatable chronic infectious disease, prevalent in South Asian countries, especially India. Before labeling a patient as a case of leprosy and starting multidrug treatment for particular type, the clinical findings should be correlated and confirmed with histopathological examination and bacteriological index of skin biopsy. Skin biopsy is an important tool in diagnosing leprosy an...

Introduction: Leprosy is a chronic granulomatous disease with widespread involvement of the body including peripheral nerves. Chronic ulcers are among the most dreaded complications of leprosy with high bacterial load resulting in delayed wound healing.The ulcers are recurrent, which increase the physical disability and mortality due to leprosy. The secondary bacterial infection in the plantar ...

tection against leprosy addressed the question of whether or not BCG was effective against leprosy. BCG vaccine trials against leprosy in South America, Africa, and Asia have demonstrated that the BCG vaccine protects against leprosy (). However the degree of protection conferred by BCG is variable between different populations as is its efficacy in the prevention of tuberculosis (). Repeated d...

Leprosy is a chronic infectious disease that can lead to physical disability, social stigma and great suffering. As the disease is transmitted person to person, it has remained endemic in some developing countries. From biblical times to the modern period, leprosy has been described as a horrifying disease due to the physical appearance of infected individuals. Leprosy results in disfigured lim...

Pure neural leprosy without cutaneous manifestations is a relatively rare manifestation of leprosy. It can present as a mono- or poly-neuritis with sensory and/or motor impairment. Neural leprosy may or may not be associated with thickening of the involved nerve. We report the case of a 14 year old boy with extensive ulnar nerve necrosis who was diagnosed to have tuberculoid leprosy. What makes...

Murine leprosy is analogous to hum an lepromatous leprosy by similarities in host cell reaotions and some characteristics of causative agents. As in the lcsions of lepromatous lcprosy so also in the lesions of murine leprosy there arc innumerable undigested bacilli and large amounts of lipids in maerophages. The present studies were initiated as a part of a series of analysis of the chemical co...

This paper presents the use of Semi-Markov model in discrete state and discrete time to study the condition of leprosy patients. Leprosy is considered to be controlled if is possible to maximize recovery and consequently minimize relapse and death. The model takes into account the concept of effectiveness of the treatment. The result shows that it is possible to attain a zero probabilities for ...

(Clarke, 1933). An article on the control of leprosy could not commence better than with the above quotation. Syphilis, tuberculosis and leprosy are the three diseases which for many decades have been under a social stigma, and of these diseases leprosy least deserves the opprobrium which has been showered upon it. Therefore, before considering the question of the prevention of leprosy, it woul...

The World Health Organization advocates 2 leprosy treatment regimens on the basis of disease classification (as multibacillary or paucibacillary) by skin lesion count. This method, which, in the Philippines, results in a high prevalence (78%) of patients with multibacillary leprosy, was directly compared with classification using standard histopathological and microbiological criteria in 264 cu...

Considering that variability in immune response genes has been associated with susceptibility to leprosy and with disease severity, leprosy presents clinicopathological variants that are highly associated with the immune response, HLA-G has a well-recognized role in the modulation of the immune response, and polymorphisms at the 3' untranslated region (UTR) of the HLA-G gene may influence HLA-G...