In sera from 12 patients with polar tuberculoid leprosy, 12 with subpolar tuberculoid leprosy, and 16 with lepromatous leprosy were demonstrated a total number of 125 anti-BCG precipitins by means of crossed immunoelectrophoresis with intermediate gel. Up to 14 different precipitins were found in individual sera, and the complexity in antibody response was higher than previously realized. The s...

The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubl...

How to cite this paper: Kaushik A, Arora D, Kolte S, Gupta K, Mandal AK. Cytological diagnosis of lepromatous nerve abscess: a case report. Annals of Pathology and Laboratory Medicine. 2014;1(2):C26-C28. Ankit Kaushik*, Disha Arora, Sachin Kolte, Kusum Gupta, A K Mandal Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India Leprosy, also known as Hen...

Rifampicin is the m ost active drug in the experimental mouse footpad infection with My co. leprae and in the treatment of human lepromatous leprosy as j udged by the rapid decline in Morphological Index . l ts definite place in the overall treatment of human leprosy needs h owever to be further ascertaine d through controlled clinicai trials exploring different thera­ peutics, also intermit te...

A lepromatous patient treated with dapsone in the pre-MDT era to the point of smear negativity (> 6 years), relapsed 5 years after stopping treatment. He was then put on WHO-MDT for multibacillary (MB) leprosy, and was treated again; he had negative slit skin smears (3 years). He again presented with a relapse of leprosy 17 years after stopping treatment, and this time he presented with borderl...

We have searched for Mycobacterium leprae DNA for 36kDa protein in urine using a M. leprae specific PCR technique. A limited number of 16 patients (of which 11 belonged to lepromatous leprosy and five to tuberculoid leprosy) and eight healthy individuals were included for the present study. The number of urine samples positive by PCR were 36.4% (4/11) in lepromatous patients and 40% (2/5) in tu...

Histoid Leprosy (HL) is a rare variant of Lepromatous Leprosy, occurring in long-standing cases, mostly in a background of acquired drug resistance. Patients usually present with sudden onset multiple nodules and plaques, most often involving the skin and subcutaneous tissue of trunk and lower limbs. Here we report an unusual case of de novo (without any history of prior anti-leprotic therapy) ...

In 1916, 1917 and 1921 the writer recorded having cleared up comparatively early outpatient cases of leprosy by injection of suitable chaulmoogra and hydnocarpate preparations. Advanced lepromatous cases in the Calcutta Leprosy asylum, however, failed to respond to this treatment. In the second paper the results were illustrated by the appearances before and after treatment, and by a coloured p...

Leprosy is a chronic and systemic infection caused by Mycobacterium leprae. According to the World Health Organization, the prevalence of leprosy registered at the beginning of 2008 stood at 212,802 cases. Thanks to anti-leprosy multidrug therapy the number of new cases detected globally has fallen. Lagophthalmos can appear in newly diagnosed lepromatous patients and in patients under anti-lepr...

One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...