نتایج جستجو برای: lentiviral vector
تعداد نتایج: 200877 فیلتر نتایج به سال:
Traditional viral vector processes rely on lab-scale methods that need to be industrialised so as avoid supply shortages during commercialisation of cell and gene therapies such CAR T-cell HSC therapies. This paper describes the application a decisional tool identify most cost-effective scalable culture technologies used in manufacture lentiviral vectors (LVs) across range products. The consist...
Lentiviral vectors are promising vaccine vector candidates that have been tested extensively in preclinical models of infectious disease and cancer immunotherapy. They are also used in gene therapy clinical trials both for the ex vivo modification of cells and for direct in vivo injection. It is therefore critical to understand the mechanism(s) by which such vectors might stimulate the immune s...
Lentiviral vectors are under intense scrutiny as unique candidate viral vector vaccines against tumor and aggressive pathogens because of their ability to initiate potent and durable specific immune responses. Strategies that alleviate safety concerns will facilitate the clinical developments involving lentiviral vectors. In this respect, the development of integration deficient lentiviral vect...
HIV-1 associated dementia remains a significant public health burden. Clinical and experimental research has shown that reduced levels of brain-derived neurotrophic factor (BDNF) may be a risk factor for neurological complications associated with HIV-1 infection. We are actively testing genetically modified macrophages for their possible use as the cell-based gene delivery vehicle for the centr...
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