Abnormal pigmentation is related to a variety of cosmetic and clinical conditions including melasma, lentigo, age spots, vitiligo, etc. Numerous actives designed to modulate skin tone have been utilized as cosmetics and pharmaceuticals to address these conditions. We report on an optimized short-term (1-week) protocol using the Asian MelanoDermTM model (MatTek Corporation) and designed to rapid...

Melanoma involving the conjunctiva is extremely rare. Graver prognosis has been reported with primary conjunctival melanoma than with their cutaneous counterparts [Collin et al.: Aust N Z J Ophthalmol 1986;14:29-34]. Among conjunctival melanomas, two significant risk factors for tumour-related death have been identified: (i) age older than 55 years and (ii) unfavourable tumour location (caruncl...

Intermittent exposure to sunlight is considered to be an important risk factor for melanoma, but the associations reported in most case-control studies are surprisingly weak. The aim of this study was to evaluate whether the incorporation of a subject's background exposure to the sun and pigmentation characteristics (which are assumed to influence a person's susceptibility to sunlight exposure)...

BACKGROUND Very little is known about possible association of nevi and melasma. The study objective was to determine if there is an association between melasma and existence of different kinds of nevi. METHODS In a case-control study, 120 female melasma patients referred to dermatology clinic of Ardabil and 120 patients referred to other specialty clinics who lacked melasma were enrolled afte...

lentiginosis prompted eval¬ uation for a unifying diagnosis. Disorders of pigmentation have been reported in association with various cardiac abnormalities, but classification remains controversial. Features of both cardiomyopathic lentiginosis2 and LEOPARD syndrome,3-5 a mnemonic code for Zentiginosis, ECG changes, ocular hypertelorism, pulmonic steno¬ sis, abnormal genitalia, growth retardati...

Several pigment-specific lasers can effectively treat epidermal and dermal pigmented lesions without complications using the basic principles of selective photothermolysis. Although such pigmented lesions as solar lentigines and nevi of Ota are relatively easy to treat using pigment-specific laser technology, café-au-lait macules and melasma show variable responses to treatment. New, long-pulse...