Noradrenaline is believed to support cognitive flexibility through the alpha 2A noradrenergic receptor (a2A-NAR) acting in prefrontal cortex. Enhanced flexibility has been inferred from improved working memory with the a2A-NA agonist Guanfacine. But it has been unclear whether Guanfacine improves specific attention and learning mechanisms beyond working memory, and whether the drug effects can ...

We report on the emergence of functional flexibility in vocalizations of human infants. This vastly underappreciated capability becomes apparent when prelinguistic vocalizations express a full range of emotional content--positive, neutral, and negative. The data show that at least three types of infant vocalizations (squeals, vowel-like sounds, and growls) occur with this full range of expressi...

For NKI it has been a major challenge to design solutions for users of mobile technology who wish to study also when on the move. Thus, when students are mobile and wishing to study, the equipment and technologies they use will be in addition to they equipment used at home or at work. The solutions must be designed in ways to allow both users and non-users of mobile technology to participate in...

The spread and abundance of electronic documents requires automatic techniques for extracting useful information from the text they contain. The availability of conceptual taxonomies can be of great help, but manually building them is a complex and costly task. Building on previous work, we propose a technique to automatically extract conceptual graphs from text and reason with them. Since auto...

Psychosocial stress influences cognitive abilities, such as long-term memory retrieval. However, less is known about the effects of stress on cognitive flexibility, which is mediated by different neurobiological circuits and could thus be regulated by different neuroendocrine pathways. In this study, we randomly assigned healthy adults to an acute stress induction or control condition and subse...

Statement of purpose: The purpose of these working papers is to promote the circulation of research results (Research Series) and analytical studies (Documents Series) made within the National Bank of Belgium or presented by external economists in seminars, conferences and conventions organised by the Bank. The aim is therefore to provide a platform for discussion. The opinions expressed are st...

The LEP energy upgrade up to fi =189 GeV has allowed us to extend substantially the potential of searches for new physics. Results on searches for Higgs bosoms and supersymmetric particles obtained by the ALEPH, DELPHI, L3, and OPAL experiments are reported. No evidence of any signal is observed. Therefore, new limits on the Higgs boson masses as well as on the masses of the various supersymmet...

We would like to congratulate Fruchter et al 1 for their ingenious, effective, and minimally invasive way of treating the very challenging condition of bronchopleural fi stulas as reported in a recent issue of CHEST (March 2011). However, because we were cited in their work, we must make a correction. The misunderstanding is that our fi rst publication was a case report of our fi rst patient (5...