The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days. The effect of these treatments on parameters indicative of oxidative stress (gl...

INTRODUCTION Use of lead acid battery (LAB) in Bangladesh has risen with sharp rise of motor vehicles. As result, manufacture of LAB is increasing. Most of the lead used by these industries comes from recycling of LAB. Workers in LAB industry are at risk of exposure lead and thus development of lead toxicity. OBJECTIVE The objective of this study was to measure the blood lead concentration an...

Matrix gamma-carboxy glutamic acid protein (MGP) is a 10-kDa secreted protein containing five residues of the vitamin K-dependent calcium binding amino acid gamma-carboxyglutamic acid (Gla). This study was carried out to examine the effects of MGP gene promoter polymorphism (T-138C) on blood lead levels (BLL) and hematological parameters in 113 battery manufacturing unit workers occupationally ...

The effect of Pb on Saccharomyces cerevisiae cell structure and function was examined. Membrane integrity was assessed by the release of UV-absorbing compounds and by the intracellular K efflux. No leakage of UV260-absorbing compounds or loss of K + were observed in Pb (until 1,000 μmol/l) treated cells up to 30 min; these results suggest that plasma membrane seems not to be the immediate and p...

T he toxicity of lead has been known for millennia and has served as a template for toxicology studies. According to some 45 000 measurements in European industrial settings spanning smelters, battery manufacturing, and foundries, the average concentration of lead in blood steadily declined from 68 mg/dl in 1970 to 35 mg/dl in 1995. In parallel with this development the introduction of non-lead...

Some earlier studies based on relatively small data sets have suggested that the month of diagnosis affects survival of breast cancer patients. This phenomenon has been suggested to be attributable to daylight-related hormonal factors. Factors related to the holidays of both the medical personnel and the women themselves might also provide the explanation. In this study we assessed the effect o...

The present study was carried out to understand the antioxidant and protective effect of Semecarpus anacardium against lead acetate induced toxicity. This was done by analyzing the phytochemicals (Flavanoids, alkaloids, resins, tannins, carbohydrates, proteins, etc.) present in the plant and by assessing the hepatoprotective efficacy of the plant against lead acetate induced albino rats. Histop...

During the past 20 years considerable attention has been focused on the epidemiologic features of childhood lead poisoning in the United States. Large numbers of children with symptomatic intoxication, as well as those with incipient symptoms, were commonplace a decade ago for physicians working in inner-city hospitals. With the recent availability of improved screening techniques, as well as a...