Background: Kidneys are the most vulnerable organs with respect to oxidative stress caused by lead poisoning. In this study, renal biomarkers were investigated in rats, exposed to lead after treatment with or without Lactobacillus fermentum. Methods: Twenty-four rats were divided into four groups of five each as follows: a) control, b) lead-exposed, c) Lactobacillus fermentum–treated, and d)...

all the producing and assembling processes exert residual stress on the pieces that may lead to structural failure. therefore, calculating the residual stress in such structures has been common in recent years. in this article, distribution of temperature and residual stress resulting from arc welding in three-pass butt joint in p91 austenitic stainless steel pipes is calculated and estimated u...

Lead is a toxic heavy metal that can cause a range of health problems. In this context, the vascular system is a particular target of the deleterious effects of lead. Lead exerts its toxicity through substitution of other divalent cations such as calcium and zinc, resulting in disruption of homeostasis. Based on the evidence that lead up-regulates endoplasmic reticulum (ER) chaperone glucose-re...

objective: in ventricular arrhythmias, due to their free radical scavenging action, antioxidant agents are usually used in the treatment of cardiovascular disease. since stress is considered as risk factor for increased mortality by causing malignant arrhythmias, the study was designed to evaluate the cardioprotective effects of ellagic acid (ea) on cacl2-induced arrhythmias in rat stress model...

Implantation and maintenance of a permanent cardiac pacing system in children remains challenging due to small patient size, congenital heart defects and somatic growth. We are developing a novel epicardial micropacemaker for children that can be implanted on the epicardium within the pericardial space via a minimally-invasive technique. The key design configurations include a novel open-coiled...

Arteries are modeled, within the framework of nonlinear elasticity, as incompressible two-layer cylindrical structures that are residually stressed through differential growth. These structures are loaded by an axial force, internal pressure and have nonlinear, anisotropic, hyperelastic response to stresses. Parameters for this model are directly related to experimental observations. The possib...

Previous studies from this laboratory have demonstrated the presence of oxidative stress and its role in the pathogenesis of lead-induced hypertension. This study was designed to determine whether oxidative stress in animals with lead-induced hypertension is associated with dysregulation of the activities of the main antioxidant enzymes, namely superoxide dismutase (SOD), catalase (CAT), and gl...

Recent studies have shown that lead causes oxidative stress by inducing the generation of reactive oxygen species (ROS) and reducing the antioxidant defense system of cells. This suggests that antioxidants may play an important role in the treatment of lead poisoning as a kind of excellent scavenger of free radicals and chelator of heavy metal. Whether tea catechins have protective effects agai...