This document provides a basis for the estimation of cancer risk from exposure to lead. Carcinogenic potencies were estimated from oral studies of the carcinogenicity of lead compounds. These estimated potencies were based upon the administered doses of lead; in some cases, it was necessary to calculate lead dose based upon the lead content of the administered compounds. The uncertainty associa...

BACKGROUND Lead is a pollutant with numerous adverse effects on health. Since it can affect blood pressure, peripheral blood vessels, and the heart, the present study aimed to evaluate the relation between occupational exposure to lead and blood pressure. MATERIALS AND METHODS This cross-sectional study included male individuals working in battery firms in Isfahan. A questionnaire covering de...

The recent introduction of an effective oral chelating agent for the reduction of a body burden of lead and the changing standards of care for children exposed to lead prompted the Committee on Drugs to review the therapy for lead intoxication. This statement reviews the pharmacology of available chelating agents. Screening standards and detailed discussions of environmental control and nutriti...

OBJECTIVE To evaluate the neuropsychological effects of current low level and previous higher levels of exposure to lead and evaluate the relation between effects of lead and bone lead. METHODS A neuropsychological test battery was given to 54 storage battery workers with well documented long term exposure to lead. The effect was studied in two subgroups: those whose blood lead had never exce...

Lead is a reproductive toxicant. Exposure to inorganic lead is detrimental to human semen quality. The studies of the risk of spontaneous abortion and congenital malformation have shown contradictory findings. The aim of the following review is to summarise the epidemiological evidence of the effects of inorganic lead on male fertility. The focus is on epidemiological studies of time-to-pregnan...

Disease of the lower motor neurone is a recognized hazard of lead toxicity, but the importance of contact with lead in the causation of motor neurone disease has not previously been ascertained. In 74 cases of motor neurone disease, 15% had a history of extensive exposure to lead, compared with 5·4% of a control group. The five year survival rate of these patients was 54%, compared with 16% in ...

The recent introduction of an effective oral chelating agent for the reduction of a body burden of lead and the changing standards of care for children exposed to lead prompted the Committee on Drugs to review the therapy for lead intoxication. This statement reviews the pharmacology of available chelating agents. Screening standards and detailed discussions of environmental control and nutriti...

We report lead exposure in four employees of a privately owned shooting range, one of whom had neurological toxicity due to lead. Increasing time worked at the range was associated with elevation of blood lead. This incident emphasizes the risk of airborne lead exposure to employees of firing ranges.